Pau Badia-i-Mompel
| Snapshot Date: 2025-11-20 13:40 -0500 (Thu, 20 Nov 2025) |
| git_url: https://git.bioconductor.org/packages/decoupleR |
| git_branch: devel |
| git_last_commit: 6d54bce |
| git_last_commit_date: 2025-10-29 11:09:41 -0500 (Wed, 29 Oct 2025) |
| Back to Multiple platform build/check report for BioC 3.23: simplified long |
|
This page was generated on 2025-11-21 11:38 -0500 (Fri, 21 Nov 2025).
| Hostname | OS | Arch (*) | R version | Installed pkgs |
|---|---|---|---|---|
| nebbiolo1 | Linux (Ubuntu 24.04.3 LTS) | x86_64 | R Under development (unstable) (2025-10-20 r88955) -- "Unsuffered Consequences" | 4829 |
| lconway | macOS 12.7.6 Monterey | x86_64 | R Under development (unstable) (2025-10-21 r88958) -- "Unsuffered Consequences" | 4602 |
| kjohnson3 | macOS 13.7.7 Ventura | arm64 | R Under development (unstable) (2025-11-04 r88984) -- "Unsuffered Consequences" | 4566 |
| Click on any hostname to see more info about the system (e.g. compilers) (*) as reported by 'uname -p', except on Windows and Mac OS X | ||||
| Package 533/2327 | Hostname | OS / Arch | INSTALL | BUILD | CHECK | BUILD BIN | ||||||||
| decoupleR 2.17.0 (landing page) Pau Badia-i-Mompel
| nebbiolo1 | Linux (Ubuntu 24.04.3 LTS) / x86_64 | OK | OK | WARNINGS | | ||||||||
| lconway | macOS 12.7.6 Monterey / x86_64 | OK | OK | WARNINGS | OK | | ||||||||
| kjohnson3 | macOS 13.7.7 Ventura / arm64 | OK | OK | ERROR | OK | |||||||||
|
To the developers/maintainers of the decoupleR package: - Allow up to 24 hours (and sometimes 48 hours) for your latest push to git@git.bioconductor.org:packages/decoupleR.git to reflect on this report. See Troubleshooting Build Report for more information. - Use the following Renviron settings to reproduce errors and warnings. - If 'R CMD check' started to fail recently on the Linux builder(s) over a missing dependency, add the missing dependency to 'Suggests:' in your DESCRIPTION file. See Renviron.bioc for more information. |
| Package: decoupleR |
| Version: 2.17.0 |
| Command: /Library/Frameworks/R.framework/Resources/bin/R CMD check --install=check:decoupleR.install-out.txt --library=/Library/Frameworks/R.framework/Resources/library --no-vignettes --timings decoupleR_2.17.0.tar.gz |
| StartedAt: 2025-11-20 20:35:47 -0500 (Thu, 20 Nov 2025) |
| EndedAt: 2025-11-20 20:45:34 -0500 (Thu, 20 Nov 2025) |
| EllapsedTime: 587.8 seconds |
| RetCode: 0 |
| Status: WARNINGS |
| CheckDir: decoupleR.Rcheck |
| Warnings: 1 |
##############################################################################
##############################################################################
###
### Running command:
###
### /Library/Frameworks/R.framework/Resources/bin/R CMD check --install=check:decoupleR.install-out.txt --library=/Library/Frameworks/R.framework/Resources/library --no-vignettes --timings decoupleR_2.17.0.tar.gz
###
##############################################################################
##############################################################################
* using log directory ‘/Users/biocbuild/bbs-3.23-bioc/meat/decoupleR.Rcheck’
* using R Under development (unstable) (2025-10-21 r88958)
* using platform: x86_64-apple-darwin20
* R was compiled by
Apple clang version 14.0.0 (clang-1400.0.29.202)
GNU Fortran (GCC) 14.2.0
* running under: macOS Ventura 13.7.8
* using session charset: UTF-8
* using option ‘--no-vignettes’
* checking for file ‘decoupleR/DESCRIPTION’ ... OK
* checking extension type ... Package
* this is package ‘decoupleR’ version ‘2.17.0’
* package encoding: UTF-8
* checking package namespace information ... OK
* checking package dependencies ... OK
* checking if this is a source package ... OK
* checking if there is a namespace ... OK
* checking for hidden files and directories ... OK
* checking for portable file names ... OK
* checking for sufficient/correct file permissions ... OK
* checking whether package ‘decoupleR’ can be installed ... OK
* checking installed package size ... OK
* checking package directory ... OK
* checking ‘build’ directory ... OK
* checking DESCRIPTION meta-information ... OK
* checking top-level files ... OK
* checking for left-over files ... OK
* checking index information ... OK
* checking package subdirectories ... OK
* checking code files for non-ASCII characters ... OK
* checking R files for syntax errors ... OK
* checking whether the package can be loaded ... OK
* checking whether the package can be loaded with stated dependencies ... OK
* checking whether the package can be unloaded cleanly ... OK
* checking whether the namespace can be loaded with stated dependencies ... OK
* checking whether the namespace can be unloaded cleanly ... OK
* checking dependencies in R code ... NOTE
[2025-11-20 20:36:24] [TRACE] [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-11-20 20:36:24] [TRACE] [OmnipathR] JSON validation successful: TRUE
[2025-11-20 20:36:24] [INFO] [OmnipathR] Initialized cache: `/Users/biocbuild/Library/Caches/OmnipathR`.
[2025-11-20 20:36:24] [INFO] [OmnipathR] Package `OmnipathR` packaged: NA
[2025-11-20 20:36:24] [INFO] [OmnipathR] Package `OmnipathR` date/publication: 2025-11-20
[2025-11-20 20:36:24] [INFO] [OmnipathR] Package `OmnipathR` built: R 4.6.0; ; 2025-11-20 20:15:50 UTC; unix
[2025-11-20 20:36:24] [INFO] [OmnipathR] Package `OmnipathR` version: 3.19.2
[2025-11-20 20:36:24] [INFO] [OmnipathR] Package `OmnipathR` repository: Bioconductor 3.23
[2025-11-20 20:36:26] [INFO] [OmnipathR] Session info: [version=R Under development (unstable) (2025-10-21 r88958); os=macOS Ventura 13.7.8; system=x86_64, darwin20; ui=X11; language=(EN); collate=C; ctype=en_US.UTF-8; tz=America/New_York; date=2025-11-20; pandoc=2.7.3 @ /usr/local/bin/ (via rmarkdown); quarto=1.4.553 @ /usr/local/bin/quarto]
[2025-11-20 20:36:26] [INFO] [OmnipathR] External libraries: [cairo=1.17.6; cairoFT=; pango=1.50.14; png=1.6.44; jpeg=9.5; tiff=LIBTIFF, Version 4.5.0; tcl=8.6; curl=8.7.1; zlib=1.2.11; bzlib=1.0.8, 13-Jul-2019; xz=5.6.3; deflate=1.23; zstd=1.5.5; PCRE=10.44 2024-06-07; ICU=70.2; TRE=TRE 0.8.0 R_fixes (BSD); iconv=Apple or GNU libiconv 1.11 /Library/Frameworks/R.framework/Versions/4.6-x86_64/Resources/lib/libR.dylib; readline=5.2; BLAS=/Library/Frameworks/R.framework/Versions/4.6-x86_64/Resources/lib/libRblas.0.dylib; lapack=/Library/Frameworks/R.framework/Versions/4.6-x86_64/Resources/lib/libRlapack.dylib; lapack_version=3.12.1]
[2025-11-20 20:36:26] [INFO] [OmnipathR] Loaded packages: abind 1.4-8(2024-09-12); annotate 1.89.0(2025-11-20); AnnotationDbi 1.73.0(2025-11-20); AUCell 1.33.0(2025-11-20); backports 1.5.0(2024-05-23); beachmat 2.27.0(2025-11-20); Biobase 2.71.0(2025-11-20); BiocGenerics 0.57.0(2025-11-20); BiocParallel 1.45.0(2025-11-20); BiocSingular 1.27.1(2025-11-20); Biostrings 2.79.2(2025-11-20); bit 4.6.0(2025-03-06); bit64 4.6.0-1(2025-01-16); blob 1.2.4(2023-03-17); cachem 1.1.0(2024-05-16); cellranger 1.1.0(2016-07-27); checkmate 2.3.3(2025-08-18); chromote 0.5.1(2025-04-24); cli 3.6.5(2025-04-23); codetools 0.2-20(2024-03-31); crayon 1.5.3(2024-06-20); curl 7.0.0(2025-08-19); data.table 1.17.8(2025-07-10); DBI 1.2.3(2024-06-02); decoupleR 2.17.0(2025-11-20); DelayedArray 0.37.0(2025-11-20); DelayedMatrixStats 1.33.0(2025-11-20); digest 0.6.39(2025-11-19); dplyr 1.1.4(2023-11-17); evaluate 1.0.5(2025-08-27); fastmap 1.2.0(2024-05-15); fs 1.6.6(2025-04-12); generics 0.1.4(2025-05-09); GenomicRanges 1.63.0(2025-11-20); glue 1.8.0(2024-09-30); graph 1.89.0(2025-11-20); GSEABase 1.73.0(2025-11-20); GSVA 2.5.8(2025-11-20); h5mread 1.3.0(2025-11-20); HDF5Array 1.39.0(2025-11-20); hms 1.1.4(2025-10-17); htmltools 0.5.8.1(2024-04-04); httr 1.4.7(2023-08-15); httr2 1.2.1(2025-07-22); igraph 2.2.1(2025-10-27); IRanges 2.45.0(2025-11-20); irlba 2.3.5.1(2022-10-03); jsonlite 2.0.0(2025-03-27); KEGGREST 1.51.1(2025-11-20); knitr 1.50(2025-03-16); later 1.4.4(2025-08-27); lattice 0.22-7(2025-04-02); lifecycle 1.0.4(2023-11-07); logger 0.4.1(2025-09-11); lubridate 1.9.4(2024-12-08); magick 2.9.0(2025-09-08); magrittr 2.0.4(2025-09-12); Matrix 1.7-4(2025-08-28); MatrixGenerics 1.23.0(2025-11-20); matrixStats 1.5.0(2025-01-07); memoise 2.0.1(2021-11-26); OmnipathR 3.19.2(2025-11-20); otel 0.2.0(2025-08-29); parallelly 1.45.1(2025-07-24); pillar 1.11.1(2025-09-17); pkgconfig 2.0.3(2019-09-22); png 0.1-8(2022-11-29); prettyunits 1.2.0(2023-09-24); processx 3.8.6(2025-02-21); progress 1.2.3(2023-12-06); promises 1.5.0(2025-11-01); ps 1.9.1(2025-04-12); purrr 1.2.0(2025-11-04); R.methodsS3 1.8.2(2022-06-13); R.oo 1.27.1(2025-05-02); R.utils 2.13.0(2025-02-24); R6 2.6.1(2025-02-15); rappdirs 0.3.3(2021-01-31); Rcpp 1.1.0(2025-07-02); readr 2.1.6(2025-11-14); readxl 1.4.5(2025-03-07); rhdf5 2.55.11(2025-11-20); rhdf5filters 1.23.1(2025-11-20); Rhdf5lib 1.33.0(2025-11-20); rjson 0.2.23(2024-09-16); rlang 1.1.6(2025-04-11); rmarkdown 2.30(2025-09-28); RSQLite 2.4.4(2025-11-10); rsvd 1.0.5(2021-04-16); rvest 1.0.5(2025-08-29); S4Arrays 1.11.0(2025-11-20); S4Vectors 0.49.0(2025-11-20); ScaledMatrix 1.19.0(2025-11-20); Seqinfo 1.1.0(2025-11-20); sessioninfo 1.2.3(2025-02-05); SingleCellExperiment 1.33.0(2025-11-20); SparseArray 1.11.2(2025-11-18); sparseMatrixStats 1.23.0(2025-11-20); SpatialExperiment 1.21.0(2025-11-20); stringi 1.8.7(2025-03-27); stringr 1.6.0(2025-11-04); SummarizedExperiment 1.41.0(2025-11-20); tibble 3.3.0(2025-06-08); tidyr 1.3.1(2024-01-24); tidyselect 1.2.1(2024-03-11); timechange 0.3.0(2024-01-18); tzdb 0.5.0(2025-03-15); vctrs 0.6.5(2023-12-01); websocket 1.4.4(2025-04-10); withr 3.0.2(2024-10-28); xfun 0.54(2025-10-30); XML 3.99-0.20(2025-11-08); xml2 1.5.0(2025-11-17); xtable 1.8-4(2019-04-21); XVector 0.51.0(2025-11-20); yaml 2.3.10(2024-07-26); zip 2.3.3(2025-05-13)
[2025-11-20 20:36:26] [INFO] [OmnipathR] CURL: version: 8.14.1; headers: 8.14.1; ssl_version: LibreSSL/3.3.6 (SecureTransport); libz_version: 1.2.11; libssh_version: NA; libidn_version: NA; host: x86_64-apple-darwin22.6.0; protocols: dict, file, ftp, ftps, gopher, gophers, http, https, imap, imaps, ldap, ldaps, mqtt, pop3, pop3s, rtsp, smb, smbs, smtp, smtps, telnet, tftp, ws, wss; ipv6: TRUE; http2: TRUE; idn: FALSE; url_parser: TRUE
[2025-11-20 20:36:26] [TRACE] [OmnipathR] Running on a build server, wiping cache.
[2025-11-20 20:36:26] [TRACE] [OmnipathR] Cache is at `/Users/biocbuild/Library/Caches/OmnipathR`.
[2025-11-20 20:36:26] [TRACE] [OmnipathR] Contains 9 files.
[2025-11-20 20:36:26] [TRACE] [OmnipathR] Cache is locked: FALSE.
[2025-11-20 20:36:26] [TRACE] [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-11-20 20:36:26] [TRACE] [OmnipathR] JSON validation successful: TRUE
[2025-11-20 20:36:26] [SUCCESS] [OmnipathR] Removing all cache contents from `/Users/biocbuild/Library/Caches/OmnipathR`.
[2025-11-20 20:36:26] [TRACE] [OmnipathR] Pandoc version: `2.7.3`.
[2025-11-20 20:36:26] [TRACE] [OmnipathR] Reading JSON from `/Library/Frameworks/R.framework/Versions/4.6-x86_64/Resources/library/OmnipathR/db/db_def.json` (encoding: UTF-8).
[2025-11-20 20:36:26] [TRACE] [OmnipathR] JSON validation successful: TRUE
[2025-11-20 20:36:26] [TRACE] [OmnipathR] Reading JSON from `/Library/Frameworks/R.framework/Versions/4.6-x86_64/Resources/library/OmnipathR/internal/magic_bytes.json` (encoding: UTF-8).
[2025-11-20 20:36:26] [TRACE] [OmnipathR] JSON validation successful: TRUE
[2025-11-20 20:36:26] [TRACE] [OmnipathR] Reading JSON from `/Library/Frameworks/R.framework/Versions/4.6-x86_64/Resources/library/OmnipathR/internal/urls.json` (encoding: UTF-8).
[2025-11-20 20:36:26] [TRACE] [OmnipathR] JSON validation successful: TRUE
[2025-11-20 20:36:26] [TRACE] [OmnipathR] Reading JSON from `/Library/Frameworks/R.framework/Versions/4.6-x86_64/Resources/library/OmnipathR/internal/id_types.json` (encoding: UTF-8).
[2025-11-20 20:36:26] [TRACE] [OmnipathR] JSON validation successful: TRUE
[2025-11-20 20:36:26] [TRACE] [OmnipathR] Cache locked: FALSE
* checking S3 generic/method consistency ... OK
* checking replacement functions ... OK
* checking foreign function calls ... OK
* checking R code for possible problems ... OK
* checking Rd files ... OK
* checking Rd metadata ... OK
* checking Rd cross-references ... WARNING
Missing link(s) in Rd file 'run_gsva.Rd':
‘GSVA::gsva’ ‘GeneSetCollection’
Non-topic package-anchored link(s) in Rd file 'pipe.Rd':
‘[magrittr:pipe]{%>%}’
See section 'Cross-references' in the 'Writing R Extensions' manual.
Found the following Rd file(s) with Rd \link{} targets missing package
anchors:
run_gsva.Rd: GSVA::gsva, GeneSetCollection
Please provide package anchors for all Rd \link{} targets not in the
package itself and the base packages.
* checking for missing documentation entries ... OK
* checking for code/documentation mismatches ... OK
* checking Rd \usage sections ... OK
* checking Rd contents ... OK
* checking for unstated dependencies in examples ... OK
* checking files in ‘vignettes’ ... OK
* checking examples ... OK
Examples with CPU (user + system) or elapsed time > 5s
user system elapsed
get_collectri 33.879 4.320 54.891
get_dorothea 26.222 1.971 31.198
run_fgsea 25.819 1.331 27.299
run_aucell 11.839 4.492 16.445
get_progeny 7.293 0.675 18.272
show_resources 0.079 0.020 6.722
* checking for unstated dependencies in ‘tests’ ... OK
* checking tests ...
Running ‘testthat.R’
OK
* checking for unstated dependencies in vignettes ... OK
* checking package vignettes ... OK
* checking running R code from vignettes ... SKIPPED
* checking re-building of vignette outputs ... SKIPPED
* checking PDF version of manual ... OK
* DONE
Status: 1 WARNING, 1 NOTE
See
‘/Users/biocbuild/bbs-3.23-bioc/meat/decoupleR.Rcheck/00check.log’
for details.
decoupleR.Rcheck/00install.out
############################################################################## ############################################################################## ### ### Running command: ### ### /Library/Frameworks/R.framework/Resources/bin/R CMD INSTALL decoupleR ### ############################################################################## ############################################################################## * installing to library ‘/Library/Frameworks/R.framework/Versions/4.6-x86_64/Resources/library’ * installing *source* package ‘decoupleR’ ... ** this is package ‘decoupleR’ version ‘2.17.0’ ** using staged installation ** R ** inst ** byte-compile and prepare package for lazy loading ** help *** installing help indices *** copying figures ** building package indices ** installing vignettes ** testing if installed package can be loaded from temporary location ** testing if installed package can be loaded from final location ** testing if installed package keeps a record of temporary installation path * DONE (decoupleR)
decoupleR.Rcheck/tests/testthat.Rout
R Under development (unstable) (2025-10-21 r88958) -- "Unsuffered Consequences"
Copyright (C) 2025 The R Foundation for Statistical Computing
Platform: x86_64-apple-darwin20
R is free software and comes with ABSOLUTELY NO WARRANTY.
You are welcome to redistribute it under certain conditions.
Type 'license()' or 'licence()' for distribution details.
R is a collaborative project with many contributors.
Type 'contributors()' for more information and
'citation()' on how to cite R or R packages in publications.
Type 'demo()' for some demos, 'help()' for on-line help, or
'help.start()' for an HTML browser interface to help.
Type 'q()' to quit R.
> library(testthat)
> library(decoupleR)
>
> test_check("decoupleR")
|
| | 0%
|
|======================================================================| 100%
|
| | 0%
|
|======================================================================| 100%
|
| | 0%
|
|======================================================================| 100%
|
| | 0%
|
|======================================================================| 100%
|
| | 0%
|
|======================================================================| 100%
|
| | 0%
|
|======================================================================| 100%
|
| | 0%
|
|======================================================================| 100%
|
| | 0%
|
|======================================================================| 100%
|
| | 0%
|
|======================================================================| 100%
|
| | 0%
|
|======================================================================| 100%
|
| | 0%
|
|======================================================================| 100%
|
| | 0%
|
|======================================================================| 100%
|
| | 0%
|
|=================================== | 50%
|
|======================================================================| 100%
|
| | 0%
|
|=================================== | 50%
|
|======================================================================| 100%
|
| | 0%
|
|=================================== | 50%
|
|======================================================================| 100%
|
| | 0%
|
|=================================== | 50%
|
|======================================================================| 100%
|
| | 0%
|
|=================================== | 50%
|
|======================================================================| 100%
|
| | 0%
|
|=================================== | 50%
|
|======================================================================| 100%
|
| | 0%
|
|=================================== | 50%
|
|======================================================================| 100%
|
| | 0%
|
|=================================== | 50%
|
|======================================================================| 100%
|
| | 0%
|
|=================================== | 50%
|
|======================================================================| 100%
|
| | 0%
|
|=================================== | 50%
|
|======================================================================| 100%
|
| | 0%
|
|=================================== | 50%
|
|======================================================================| 100%
|
| | 0%
|
|=================================== | 50%
|
|======================================================================| 100%
Warning: stack imbalance in '.Call', 162 then 163
[2025-11-20 20:41:01] [TRACE] [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-11-20 20:41:01] [TRACE] [OmnipathR] JSON validation successful: TRUE
[2025-11-20 20:41:01] [INFO] [OmnipathR] Initialized cache: `/Users/biocbuild/Library/Caches/OmnipathR`.
[2025-11-20 20:41:01] [INFO] [OmnipathR] Package `OmnipathR` packaged: NA
[2025-11-20 20:41:01] [INFO] [OmnipathR] Package `OmnipathR` date/publication: 2025-11-20
[2025-11-20 20:41:01] [INFO] [OmnipathR] Package `OmnipathR` built: R 4.6.0; ; 2025-11-20 20:15:50 UTC; unix
[2025-11-20 20:41:01] [INFO] [OmnipathR] Package `OmnipathR` version: 3.19.2
[2025-11-20 20:41:01] [INFO] [OmnipathR] Package `OmnipathR` repository: Bioconductor 3.23
[2025-11-20 20:41:03] [INFO] [OmnipathR] Session info: [version=R Under development (unstable) (2025-10-21 r88958); os=macOS Ventura 13.7.8; system=x86_64, darwin20; ui=X11; language=C; collate=C; ctype=en_US.UTF-8; tz=America/New_York; date=2025-11-20; pandoc=2.7.3 @ /usr/local/bin/ (via rmarkdown); quarto=1.4.553 @ /usr/local/bin/quarto]
[2025-11-20 20:41:03] [INFO] [OmnipathR] External libraries: [cairo=1.17.6; cairoFT=; pango=1.50.14; png=1.6.44; jpeg=9.5; tiff=LIBTIFF, Version 4.5.0; tcl=8.6; curl=8.7.1; zlib=1.2.11; bzlib=1.0.8, 13-Jul-2019; xz=5.6.3; deflate=1.23; zstd=1.5.5; PCRE=10.44 2024-06-07; ICU=70.2; TRE=TRE 0.8.0 R_fixes (BSD); iconv=Apple or GNU libiconv 1.11 /Library/Frameworks/R.framework/Versions/4.6-x86_64/Resources/lib/libR.dylib; readline=5.2; BLAS=/Library/Frameworks/R.framework/Versions/4.6-x86_64/Resources/lib/libRblas.0.dylib; lapack=/Library/Frameworks/R.framework/Versions/4.6-x86_64/Resources/lib/libRlapack.dylib; lapack_version=3.12.1]
[2025-11-20 20:41:04] [INFO] [OmnipathR] Loaded packages: abind 1.4-8(2024-09-12); annotate 1.89.0(2025-11-20); AnnotationDbi 1.73.0(2025-11-20); AUCell 1.33.0(2025-11-20); backports 1.5.0(2024-05-23); beachmat 2.27.0(2025-11-20); Biobase 2.71.0(2025-11-20); BiocGenerics 0.57.0(2025-11-20); BiocParallel 1.45.0(2025-11-20); BiocSingular 1.27.1(2025-11-20); Biostrings 2.79.2(2025-11-20); bit 4.6.0(2025-03-06); bit64 4.6.0-1(2025-01-16); blob 1.2.4(2023-03-17); brio 1.1.5(2024-04-24); broom 1.0.10(2025-09-13); cachem 1.1.0(2024-05-16); cellranger 1.1.0(2016-07-27); checkmate 2.3.3(2025-08-18); chromote 0.5.1(2025-04-24); class 7.3-23(2025-01-01); cli 3.6.5(2025-04-23); codetools 0.2-20(2024-03-31); cowplot 1.2.0(2025-07-07); crayon 1.5.3(2024-06-20); curl 7.0.0(2025-08-19); data.table 1.17.8(2025-07-10); DBI 1.2.3(2024-06-02); decoupleR 2.17.0(2025-11-20); DelayedArray 0.37.0(2025-11-20); DelayedMatrixStats 1.33.0(2025-11-20); desc 1.4.3(2023-12-10); dichromat 2.0-0.1(2022-05-02); digest 0.6.39(2025-11-19); dplyr 1.1.4(2023-11-17); e1071 1.7-16(2024-09-16); evaluate 1.0.5(2025-08-27); farver 2.1.2(2024-05-13); fastmap 1.2.0(2024-05-15); fastmatch 1.1-6(2024-12-23); fgsea 1.37.0(2025-11-20); fs 1.6.6(2025-04-12); generics 0.1.4(2025-05-09); GenomicRanges 1.63.0(2025-11-20); ggplot2 4.0.1(2025-11-14); glue 1.8.0(2024-09-30); graph 1.89.0(2025-11-20); GSEABase 1.73.0(2025-11-20); GSVA 2.5.8(2025-11-20); gtable 0.3.6(2024-10-25); h5mread 1.3.0(2025-11-20); HDF5Array 1.39.0(2025-11-20); hms 1.1.4(2025-10-17); htmltools 0.5.8.1(2024-04-04); htmlwidgets 1.6.4(2023-12-06); httr 1.4.7(2023-08-15); httr2 1.2.1(2025-07-22); igraph 2.2.1(2025-10-27); IRanges 2.45.0(2025-11-20); irlba 2.3.5.1(2022-10-03); jsonlite 2.0.0(2025-03-27); KEGGREST 1.51.1(2025-11-20); kernlab 0.9-33(2024-08-13); KernSmooth 2.23-26(2025-01-01); knitr 1.50(2025-03-16); later 1.4.4(2025-08-27); lattice 0.22-7(2025-04-02); lazyeval 0.2.2(2019-03-15); lifecycle 1.0.4(2023-11-07); logger 0.4.1(2025-09-11); lubridate 1.9.4(2024-12-08); magick 2.9.0(2025-09-08); magrittr 2.0.4(2025-09-12); MASS 7.3-65(2025-02-28); Matrix 1.7-4(2025-08-28); MatrixGenerics 1.23.0(2025-11-20); matrixStats 1.5.0(2025-01-07); memoise 2.0.1(2021-11-26); mixtools 2.0.0.1(2025-03-08); nlme 3.1-168(2025-03-31); OmnipathR 3.19.2(2025-11-20); otel 0.2.0(2025-08-29); parallelly 1.45.1(2025-07-24); pillar 1.11.1(2025-09-17); pkgconfig 2.0.3(2019-09-22); plotly 4.11.0(2025-06-19); png 0.1-8(2022-11-29); prettyunits 1.2.0(2023-09-24); processx 3.8.6(2025-02-21); progress 1.2.3(2023-12-06); promises 1.5.0(2025-11-01); proxy 0.4-27(2022-06-09); ps 1.9.1(2025-04-12); purrr 1.2.0(2025-11-04); R.methodsS3 1.8.2(2022-06-13); R.oo 1.27.1(2025-05-02); R.utils 2.13.0(2025-02-24); R6 2.6.1(2025-02-15); ranger 0.17.0(2024-11-08); rappdirs 0.3.3(2021-01-31); RColorBrewer 1.1-3(2022-04-03); Rcpp 1.1.0(2025-07-02); readr 2.1.6(2025-11-14); readxl 1.4.5(2025-03-07); rhdf5 2.55.11(2025-11-20); rhdf5filters 1.23.1(2025-11-20); Rhdf5lib 1.33.0(2025-11-20); rjson 0.2.23(2024-09-16); rlang 1.1.6(2025-04-11); rmarkdown 2.30(2025-09-28); rpart 4.1.24(2025-01-07); RSQLite 2.4.4(2025-11-10); rsvd 1.0.5(2021-04-16); rvest 1.0.5(2025-08-29); S4Arrays 1.11.0(2025-11-20); S4Vectors 0.49.0(2025-11-20); S7 0.2.1(2025-11-14); ScaledMatrix 1.19.0(2025-11-20); scales 1.4.0(2025-04-24); segmented 2.1-4(2025-02-28); Seqinfo 1.1.0(2025-11-20); sessioninfo 1.2.3(2025-02-05); SingleCellExperiment 1.33.0(2025-11-20); SparseArray 1.11.2(2025-11-18); sparseMatrixStats 1.23.0(2025-11-20); SpatialExperiment 1.21.0(2025-11-20); stringi 1.8.7(2025-03-27); stringr 1.6.0(2025-11-04); SummarizedExperiment 1.41.0(2025-11-20); survival 3.8-3(2024-12-17); testthat 3.3.0(2025-11-13); tibble 3.3.0(2025-06-08); tidyr 1.3.1(2024-01-24); tidyselect 1.2.1(2024-03-11); timechange 0.3.0(2024-01-18); tzdb 0.5.0(2025-03-15); vctrs 0.6.5(2023-12-01); viper 1.45.0(2025-11-20); viridisLite 0.4.2(2023-05-02); waldo 0.6.2(2025-07-11); websocket 1.4.4(2025-04-10); withr 3.0.2(2024-10-28); xfun 0.54(2025-10-30); XML 3.99-0.20(2025-11-08); xml2 1.5.0(2025-11-17); xtable 1.8-4(2019-04-21); XVector 0.51.0(2025-11-20); yaml 2.3.10(2024-07-26); zip 2.3.3(2025-05-13)
[2025-11-20 20:41:04] [INFO] [OmnipathR] CURL: version: 8.14.1; headers: 8.14.1; ssl_version: LibreSSL/3.3.6 (SecureTransport); libz_version: 1.2.11; libssh_version: NA; libidn_version: NA; host: x86_64-apple-darwin22.6.0; protocols: dict, file, ftp, ftps, gopher, gophers, http, https, imap, imaps, ldap, ldaps, mqtt, pop3, pop3s, rtsp, smb, smbs, smtp, smtps, telnet, tftp, ws, wss; ipv6: TRUE; http2: TRUE; idn: FALSE; url_parser: TRUE
[2025-11-20 20:41:04] [TRACE] [OmnipathR] Running on a build server, wiping cache.
[2025-11-20 20:41:04] [TRACE] [OmnipathR] Cache is at `/Users/biocbuild/Library/Caches/OmnipathR`.
[2025-11-20 20:41:04] [TRACE] [OmnipathR] Contains 9 files.
[2025-11-20 20:41:04] [TRACE] [OmnipathR] Cache is locked: FALSE.
[2025-11-20 20:41:04] [TRACE] [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-11-20 20:41:04] [TRACE] [OmnipathR] JSON validation successful: TRUE
[2025-11-20 20:41:04] [SUCCESS] [OmnipathR] Removing all cache contents from `/Users/biocbuild/Library/Caches/OmnipathR`.
[2025-11-20 20:41:04] [TRACE] [OmnipathR] Pandoc version: `2.7.3`.
[2025-11-20 20:41:04] [TRACE] [OmnipathR] Reading JSON from `/Library/Frameworks/R.framework/Versions/4.6-x86_64/Resources/library/OmnipathR/db/db_def.json` (encoding: UTF-8).
[2025-11-20 20:41:04] [TRACE] [OmnipathR] JSON validation successful: TRUE
[2025-11-20 20:41:04] [TRACE] [OmnipathR] Reading JSON from `/Library/Frameworks/R.framework/Versions/4.6-x86_64/Resources/library/OmnipathR/internal/magic_bytes.json` (encoding: UTF-8).
[2025-11-20 20:41:04] [TRACE] [OmnipathR] JSON validation successful: TRUE
[2025-11-20 20:41:04] [TRACE] [OmnipathR] Reading JSON from `/Library/Frameworks/R.framework/Versions/4.6-x86_64/Resources/library/OmnipathR/internal/urls.json` (encoding: UTF-8).
[2025-11-20 20:41:04] [TRACE] [OmnipathR] JSON validation successful: TRUE
[2025-11-20 20:41:04] [TRACE] [OmnipathR] Reading JSON from `/Library/Frameworks/R.framework/Versions/4.6-x86_64/Resources/library/OmnipathR/internal/id_types.json` (encoding: UTF-8).
[2025-11-20 20:41:04] [TRACE] [OmnipathR] JSON validation successful: TRUE
[2025-11-20 20:41:04] [TRACE] [OmnipathR] Cache locked: FALSE
[2025-11-20 20:41:04] [TRACE] [OmnipathR] Reading JSON from `https://omnipathdb.org/resources` (encoding: UTF-8).
[2025-11-20 20:41:05] [TRACE] [OmnipathR] JSON validation successful: TRUE
[2025-11-20 20:41:05] [TRACE] [OmnipathR] Reading JSON from `https://omnipathdb.org/resources` (encoding: UTF-8).
[2025-11-20 20:41:06] [TRACE] [OmnipathR] JSON validation successful: TRUE
[2025-11-20 20:41:06] [INFO] [OmnipathR] Loading database `Ensembl and OMA organism names`.
[2025-11-20 20:41:06] [TRACE] [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-11-20 20:41:06] [TRACE] [OmnipathR] JSON validation successful: TRUE
[2025-11-20 20:41:06] [INFO] [OmnipathR] Looking up in cache `https://rescued.omnipathdb.org/ensembl-species.html`: key=67b4943ae7fd646a03b760aefa99fe6c41ab2887, no version available.
[2025-11-20 20:41:06] [TRACE] [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-11-20 20:41:06] [TRACE] [OmnipathR] JSON validation successful: TRUE
[2025-11-20 20:41:06] [INFO] [OmnipathR] Created new version for cache record 67b4943ae7fd646a03b760aefa99fe6c41ab2887: version 1.
[2025-11-20 20:41:06] [TRACE] [OmnipathR] Cache file path: /Users/biocbuild/Library/Caches/OmnipathR/67b4943ae7fd646a03b760aefa99fe6c41ab2887-1.html
[2025-11-20 20:41:06] [INFO] [OmnipathR] Retrieving URL: `https://rescued.omnipathdb.org/ensembl-species.html`
[2025-11-20 20:41:06] [TRACE] [OmnipathR] Downloading by `httr2` in `download_base`.
[2025-11-20 20:41:06] [TRACE] [OmnipathR] Attempt 1/3: `https://rescued.omnipathdb.org/ensembl-species.html`
[2025-11-20 20:41:06] [TRACE] [OmnipathR] Preparing httr2 request to URL `https://rescued.omnipathdb.org/ensembl-species.html`.
[2025-11-20 20:41:06] [TRACE] [OmnipathR] HTTP headers: [User-Agent=Mozilla/5.0 (X11; Linux x86_64; rv:134.0) Gecko/20100101 Firefox/134.0]
[2025-11-20 20:41:06] [TRACE] [OmnipathR] Curl options: [connecttimeout=10,timeout=300,debugfunction=<function>,verbose=FALSE,tcp_keepalive=TRUE,tcp_keepintvl=10,tcp_keepidle=10,tcp_keepcnt=13,upkeep_interval_ms=30000,ssl_verifypeer=1,ssl_verifyhost=2]
[2025-11-20 20:41:06] [TRACE] [OmnipathR] HTTP headers: [User-Agent=Mozilla/5.0 (X11; Linux x86_64; rv:134.0) Gecko/20100101 Firefox/134.0]
[2025-11-20 20:41:06] [TRACE] [OmnipathR] Sending HTTP request.
[2025-11-20 20:41:07] [TRACE] [OmnipathR] HTTP 200 (OK)
[2025-11-20 20:41:07] [TRACE] [OmnipathR] HTTP v1 GET: status 200.
[2025-11-20 20:41:07] [TRACE] [OmnipathR] Downloaded 39.9 Kb in 0.650882s from rescued.omnipathdb.org (61.2 Kb/s); Redirect: 0s, DNS look up: 0.001273s, Connection: 0.002346s, Pretransfer: 0.326267s, First byte at: 0.490047s
[2025-11-20 20:41:07] [TRACE] [OmnipathR] HTTP headers: HTTP/1.1 200 OK; Server: nginx; Date: Fri, 21 Nov 2025 01:41:06 GMT; Content-Type: text/html; charset=utf-8; Last-Modified: Fri, 24 Oct 2025 17:07:34 GMT; Transfer-Encoding: chunked; Connection: keep-alive; ETag: W/"68fbb256-3f5d0"; Expires: Fri, 21 Nov 2025 02:41:06 GMT; Cache-Control: max-age=3600; Cache-Control: public; X-Frame-Options: DENY; Content-Encoding: gzip
[2025-11-20 20:41:07] [TRACE] [OmnipathR] Response headers: [Server=nginx,Date=Fri, 21 Nov 2025 01:41:06 GMT,Content-Type=text/html; charset=utf-8,Last-Modified=Fri, 24 Oct 2025 17:07:34 GMT,Transfer-Encoding=chunked,Connection=keep-alive,ETag=W/"68fbb256-3f5d0",Expires=Fri, 21 Nov 2025 02:41:06 GMT,Cache-Control=max-age=3600,Cache-Control=public,X-Frame-Options=DENY,Content-Encoding=gzip]
[2025-11-20 20:41:08] [INFO] [OmnipathR] Download ready [key=67b4943ae7fd646a03b760aefa99fe6c41ab2887, version=1]
[2025-11-20 20:41:08] [TRACE] [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-11-20 20:41:08] [TRACE] [OmnipathR] JSON validation successful: TRUE
[2025-11-20 20:41:08] [INFO] [OmnipathR] Cache item `67b4943ae7fd646a03b760aefa99fe6c41ab2887` version 1: status changed from `unknown` to `ready`.
[2025-11-20 20:41:08] [TRACE] [OmnipathR] Downloading by `generic_downloader`.
[2025-11-20 20:41:09] [TRACE] [OmnipathR] Looking up in cache: `https://omabrowser.org/All/oma-species.txt`.
[2025-11-20 20:41:09] [INFO] [OmnipathR] Cache record does not exist: `https://omabrowser.org/All/oma-species.txt`
[2025-11-20 20:41:09] [TRACE] [OmnipathR] Could not find in cache, initiating download: `https://omabrowser.org/All/oma-species.txt`.
[2025-11-20 20:41:09] [TRACE] [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-11-20 20:41:09] [TRACE] [OmnipathR] JSON validation successful: TRUE
[2025-11-20 20:41:09] [TRACE] [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-11-20 20:41:09] [TRACE] [OmnipathR] JSON validation successful: TRUE
[2025-11-20 20:41:09] [INFO] [OmnipathR] Cache item `30e690cbb55dfc63b5903ab337f34ffc2f4be397` version 1: status changed from `unknown` to `started`.
[2025-11-20 20:41:09] [TRACE] [OmnipathR] Exporting object to RDS: `/Users/biocbuild/Library/Caches/OmnipathR/30e690cbb55dfc63b5903ab337f34ffc2f4be397-1.rds`.
[2025-11-20 20:41:09] [INFO] [OmnipathR] Retrieving URL: `https://omabrowser.org/All/oma-species.txt`
[2025-11-20 20:41:09] [TRACE] [OmnipathR] Attempt 1/3: `https://omabrowser.org/All/oma-species.txt`
[2025-11-20 20:41:09] [TRACE] [OmnipathR] HTTP request by `omnipath_curl`.
[2025-11-20 20:41:09] [TRACE] [OmnipathR] Curl options: [connecttimeout=10,timeout=300,debugfunction=<function>,verbose=FALSE,tcp_keepalive=TRUE,tcp_keepintvl=10,tcp_keepidle=10,tcp_keepcnt=13,upkeep_interval_ms=30000,ssl_verifypeer=1,ssl_verifyhost=2]
[2025-11-20 20:41:09] [TRACE] [OmnipathR] HTTP v2 GET: status 200.
[2025-11-20 20:41:09] [TRACE] [OmnipathR] Downloaded 8.7 Kb in 0.51445s from omabrowser.org (16.9 Kb/s); Redirect: 0s, DNS look up: 0.001266s, Connection: 0.002353s, Pretransfer: 0.41156s, First byte at: 0.514163s
[2025-11-20 20:41:09] [TRACE] [OmnipathR] HTTP headers: HTTP/2 200 ; date: Fri, 21 Nov 2025 01:41:09 GMT; server: nginx; strict-transport-security: max-age=31536000; includeSubDomains; content-type: text/plain; charset=UTF-8; last-modified: Wed, 20 Nov 2024 10:20:02 GMT; etag: W/"673db7d2-6517f"; access-control-allow-origin: *; content-encoding: gzip
[2025-11-20 20:41:11] [TRACE] [OmnipathR] Exported RDS to `/Users/biocbuild/Library/Caches/OmnipathR/30e690cbb55dfc63b5903ab337f34ffc2f4be397-1.rds`.
[2025-11-20 20:41:11] [INFO] [OmnipathR] Download ready [key=30e690cbb55dfc63b5903ab337f34ffc2f4be397, version=1]
[2025-11-20 20:41:11] [TRACE] [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-11-20 20:41:11] [TRACE] [OmnipathR] JSON validation successful: TRUE
[2025-11-20 20:41:11] [INFO] [OmnipathR] Cache item `30e690cbb55dfc63b5903ab337f34ffc2f4be397` version 1: status changed from `started` to `ready`.
[2025-11-20 20:41:11] [TRACE] [OmnipathR] Downloading by `generic_downloader`.
[2025-11-20 20:41:11] [TRACE] [OmnipathR] Looking up in cache: `https://ftp.expasy.org/databases/uniprot/current_release/knowledgebase/complete/docs/speclist.txt`.
[2025-11-20 20:41:11] [INFO] [OmnipathR] Cache record does not exist: `https://ftp.expasy.org/databases/uniprot/current_release/knowledgebase/complete/docs/speclist.txt`
[2025-11-20 20:41:11] [TRACE] [OmnipathR] Could not find in cache, initiating download: `https://ftp.expasy.org/databases/uniprot/current_release/knowledgebase/complete/docs/speclist.txt`.
[2025-11-20 20:41:11] [TRACE] [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-11-20 20:41:11] [TRACE] [OmnipathR] JSON validation successful: TRUE
[2025-11-20 20:41:11] [TRACE] [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-11-20 20:41:11] [TRACE] [OmnipathR] JSON validation successful: TRUE
[2025-11-20 20:41:11] [INFO] [OmnipathR] Cache item `56ad6544dc07a2222fa6013d8d83e6e5a35fdf33` version 1: status changed from `unknown` to `started`.
[2025-11-20 20:41:11] [TRACE] [OmnipathR] Exporting object to RDS: `/Users/biocbuild/Library/Caches/OmnipathR/56ad6544dc07a2222fa6013d8d83e6e5a35fdf33-1.rds`.
[2025-11-20 20:41:11] [INFO] [OmnipathR] Retrieving URL: `https://ftp.expasy.org/databases/uniprot/current_release/knowledgebase/complete/docs/speclist.txt`
[2025-11-20 20:41:11] [TRACE] [OmnipathR] Attempt 1/3: `https://ftp.expasy.org/databases/uniprot/current_release/knowledgebase/complete/docs/speclist.txt`
[2025-11-20 20:41:53] [TRACE] [OmnipathR] Exported RDS to `/Users/biocbuild/Library/Caches/OmnipathR/56ad6544dc07a2222fa6013d8d83e6e5a35fdf33-1.rds`.
[2025-11-20 20:41:53] [INFO] [OmnipathR] Download ready [key=56ad6544dc07a2222fa6013d8d83e6e5a35fdf33, version=1]
[2025-11-20 20:41:53] [TRACE] [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-11-20 20:41:53] [TRACE] [OmnipathR] JSON validation successful: TRUE
[2025-11-20 20:41:53] [INFO] [OmnipathR] Cache item `56ad6544dc07a2222fa6013d8d83e6e5a35fdf33` version 1: status changed from `started` to `ready`.
[2025-11-20 20:41:53] [INFO] [OmnipathR] Loaded database `Ensembl and OMA organism names`.
[2025-11-20 20:41:53] [TRACE] [OmnipathR] Processing args for OmniPath query
[2025-11-20 20:41:53] [TRACE] [OmnipathR] Arguments for OmniPath query: [wide=TRUE,resources=TFcensus,query_type=annotations]
[2025-11-20 20:41:53] [TRACE] [OmnipathR] Organism(s): 9606
[2025-11-20 20:41:53] [TRACE] [OmnipathR] Orthology targets:
[2025-11-20 20:41:53] [TRACE] [OmnipathR] Reading JSON from `https://omnipathdb.org/resources` (encoding: UTF-8).
[2025-11-20 20:41:54] [TRACE] [OmnipathR] JSON validation successful: TRUE
[2025-11-20 20:41:54] [TRACE] [OmnipathR] Looking up in cache: `https://omnipathdb.org/annotations?resources=TFcensus&license=academic`
[2025-11-20 20:41:54] [INFO] [OmnipathR] Cache record does not exist: `https://omnipathdb.org/annotations?resources=TFcensus&license=academic`
[2025-11-20 20:41:54] [TRACE] [OmnipathR] Looking up in cache: `http://no-tls.omnipathdb.org/annotations?resources=TFcensus&license=academic`
[2025-11-20 20:41:54] [INFO] [OmnipathR] Cache record does not exist: `http://no-tls.omnipathdb.org/annotations?resources=TFcensus&license=academic`
[2025-11-20 20:41:54] [TRACE] [OmnipathR] Attempting `https://omnipathdb.org/annotations?resources=TFcensus&license=academic`
[2025-11-20 20:41:54] [INFO] [OmnipathR] Retrieving URL: `https://omnipathdb.org/annotations?resources=TFcensus&license=academic`
[2025-11-20 20:41:54] [TRACE] [OmnipathR] Attempt 1/3: `https://omnipathdb.org/annotations?resources=TFcensus&license=academic`
[2025-11-20 20:41:54] [TRACE] [OmnipathR] HTTP request by `omnipath_curl`.
[2025-11-20 20:41:54] [TRACE] [OmnipathR] Curl options: [connecttimeout=10,timeout=300,debugfunction=<function>,verbose=FALSE,tcp_keepalive=TRUE,tcp_keepintvl=10,tcp_keepidle=10,tcp_keepcnt=13,upkeep_interval_ms=30000,ssl_verifypeer=1,ssl_verifyhost=2]
[2025-11-20 20:41:55] [TRACE] [OmnipathR] HTTP v1 GET: status 200.
[2025-11-20 20:41:55] [TRACE] [OmnipathR] Downloaded 15.7 Kb in 0.316107s from omnipathdb.org (49.6 Kb/s); Redirect: 0s, DNS look up: 0.00112s, Connection: 0.001911s, Pretransfer: 0.159333s, First byte at: 0.315734s
[2025-11-20 20:41:55] [TRACE] [OmnipathR] HTTP headers: HTTP/1.1 200 OK; Server: nginx; Date: Fri, 21 Nov 2025 01:41:55 GMT; Content-Type: text/plain; charset=utf-8; Transfer-Encoding: chunked; Connection: keep-alive; Cache-Control: max-age=3600; Access-Control-Allow-Origin: *; Expires: Fri, 21 Nov 2025 02:41:55 GMT; Cache-Control: public; X-Frame-Options: DENY; Content-Encoding: gzip
[2025-11-20 20:41:56] [INFO] [OmnipathR] Successfully retrieved: `https://omnipathdb.org/annotations?resources=TFcensus&license=academic`
[2025-11-20 20:41:56] [TRACE] [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-11-20 20:41:56] [TRACE] [OmnipathR] JSON validation successful: TRUE
[2025-11-20 20:41:56] [TRACE] [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-11-20 20:41:56] [TRACE] [OmnipathR] JSON validation successful: TRUE
[2025-11-20 20:41:56] [INFO] [OmnipathR] Cache item `6f000d9b5edd9832b1c28754d1c3d9449c1c7490` version 1: status changed from `unknown` to `started`.
[2025-11-20 20:41:56] [TRACE] [OmnipathR] Exporting object to RDS: `/Users/biocbuild/Library/Caches/OmnipathR/6f000d9b5edd9832b1c28754d1c3d9449c1c7490-1.rds`.
[2025-11-20 20:41:56] [TRACE] [OmnipathR] Exported RDS to `/Users/biocbuild/Library/Caches/OmnipathR/6f000d9b5edd9832b1c28754d1c3d9449c1c7490-1.rds`.
[2025-11-20 20:41:56] [INFO] [OmnipathR] Download ready [key=6f000d9b5edd9832b1c28754d1c3d9449c1c7490, version=1]
[2025-11-20 20:41:56] [TRACE] [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-11-20 20:41:56] [TRACE] [OmnipathR] JSON validation successful: TRUE
[2025-11-20 20:41:56] [INFO] [OmnipathR] Cache item `6f000d9b5edd9832b1c28754d1c3d9449c1c7490` version 1: status changed from `started` to `ready`.
[2025-11-20 20:41:56] [SUCCESS] [OmnipathR] Downloaded 3497 annotation records.
[2025-11-20 20:41:56] [TRACE] [OmnipathR] Reading JSON from `https://omnipathdb.org/resources` (encoding: UTF-8).
[2025-11-20 20:41:56] [TRACE] [OmnipathR] JSON validation successful: TRUE
[2025-11-20 20:41:56] [TRACE] [OmnipathR] Processing args for OmniPath query
[2025-11-20 20:41:56] [TRACE] [OmnipathR] Arguments for OmniPath query: [wide=TRUE,resources=PROGENy,query_type=annotations]
[2025-11-20 20:41:57] [TRACE] [OmnipathR] Organism(s): 9606
[2025-11-20 20:41:57] [TRACE] [OmnipathR] Orthology targets:
[2025-11-20 20:41:57] [TRACE] [OmnipathR] Reading JSON from `https://omnipathdb.org/resources` (encoding: UTF-8).
[2025-11-20 20:41:57] [TRACE] [OmnipathR] JSON validation successful: TRUE
[2025-11-20 20:41:57] [TRACE] [OmnipathR] Looking up in cache: `https://omnipathdb.org/annotations?resources=PROGENy&license=academic`
[2025-11-20 20:41:57] [INFO] [OmnipathR] Cache record does not exist: `https://omnipathdb.org/annotations?resources=PROGENy&license=academic`
[2025-11-20 20:41:57] [TRACE] [OmnipathR] Looking up in cache: `http://no-tls.omnipathdb.org/annotations?resources=PROGENy&license=academic`
[2025-11-20 20:41:57] [INFO] [OmnipathR] Cache record does not exist: `http://no-tls.omnipathdb.org/annotations?resources=PROGENy&license=academic`
[2025-11-20 20:41:57] [TRACE] [OmnipathR] Attempting `https://omnipathdb.org/annotations?resources=PROGENy&license=academic`
[2025-11-20 20:41:57] [INFO] [OmnipathR] Retrieving URL: `https://omnipathdb.org/annotations?resources=PROGENy&license=academic`
[2025-11-20 20:41:57] [TRACE] [OmnipathR] Attempt 1/3: `https://omnipathdb.org/annotations?resources=PROGENy&license=academic`
[2025-11-20 20:41:57] [TRACE] [OmnipathR] HTTP request by `omnipath_curl`.
[2025-11-20 20:41:57] [TRACE] [OmnipathR] Curl options: [connecttimeout=10,timeout=300,debugfunction=<function>,verbose=FALSE,tcp_keepalive=TRUE,tcp_keepintvl=10,tcp_keepidle=10,tcp_keepcnt=13,upkeep_interval_ms=30000,ssl_verifypeer=1,ssl_verifyhost=2]
[2025-11-20 20:41:58] [TRACE] [OmnipathR] HTTP v1 GET: status 200.
[2025-11-20 20:41:58] [TRACE] [OmnipathR] Downloaded 15.7 Kb in 0.341641s from omnipathdb.org (45.9 Kb/s); Redirect: 0s, DNS look up: 0.001199s, Connection: 0.002199s, Pretransfer: 0.175901s, First byte at: 0.341227s
[2025-11-20 20:41:58] [TRACE] [OmnipathR] HTTP headers: HTTP/1.1 200 OK; Server: nginx; Date: Fri, 21 Nov 2025 01:41:58 GMT; Content-Type: text/plain; charset=utf-8; Transfer-Encoding: chunked; Connection: keep-alive; Cache-Control: max-age=3600; Access-Control-Allow-Origin: *; Expires: Fri, 21 Nov 2025 02:41:58 GMT; Cache-Control: public; X-Frame-Options: DENY; Content-Encoding: gzip
[2025-11-20 20:42:07] [INFO] [OmnipathR] Successfully retrieved: `https://omnipathdb.org/annotations?resources=PROGENy&license=academic`
[2025-11-20 20:42:07] [TRACE] [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-11-20 20:42:07] [TRACE] [OmnipathR] JSON validation successful: TRUE
[2025-11-20 20:42:07] [TRACE] [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-11-20 20:42:07] [TRACE] [OmnipathR] JSON validation successful: TRUE
[2025-11-20 20:42:07] [INFO] [OmnipathR] Cache item `3492392585ba05414edfae46801492076437d7e7` version 1: status changed from `unknown` to `started`.
[2025-11-20 20:42:07] [TRACE] [OmnipathR] Exporting object to RDS: `/Users/biocbuild/Library/Caches/OmnipathR/3492392585ba05414edfae46801492076437d7e7-1.rds`.
[2025-11-20 20:42:10] [TRACE] [OmnipathR] Exported RDS to `/Users/biocbuild/Library/Caches/OmnipathR/3492392585ba05414edfae46801492076437d7e7-1.rds`.
[2025-11-20 20:42:10] [INFO] [OmnipathR] Download ready [key=3492392585ba05414edfae46801492076437d7e7, version=1]
[2025-11-20 20:42:10] [TRACE] [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-11-20 20:42:10] [TRACE] [OmnipathR] JSON validation successful: TRUE
[2025-11-20 20:42:10] [INFO] [OmnipathR] Cache item `3492392585ba05414edfae46801492076437d7e7` version 1: status changed from `started` to `ready`.
[2025-11-20 20:42:10] [SUCCESS] [OmnipathR] Downloaded 699831 annotation records.
[2025-11-20 20:42:12] [TRACE] [OmnipathR] Reading JSON from `https://omnipathdb.org/resources` (encoding: UTF-8).
[2025-11-20 20:42:12] [TRACE] [OmnipathR] JSON validation successful: TRUE
[2025-11-20 20:42:12] [TRACE] [OmnipathR] Processing args for OmniPath query
[2025-11-20 20:42:12] [TRACE] [OmnipathR] Arguments for OmniPath query: [wide=TRUE,resources=PROGENy,query_type=annotations]
[2025-11-20 20:42:12] [TRACE] [OmnipathR] Organism(s): 9606
[2025-11-20 20:42:13] [TRACE] [OmnipathR] Orthology targets:
[2025-11-20 20:42:13] [TRACE] [OmnipathR] Reading JSON from `https://omnipathdb.org/resources` (encoding: UTF-8).
[2025-11-20 20:42:13] [TRACE] [OmnipathR] JSON validation successful: TRUE
[2025-11-20 20:42:13] [TRACE] [OmnipathR] Looking up in cache: `https://omnipathdb.org/annotations?resources=PROGENy&license=academic`
[2025-11-20 20:42:15] [TRACE] [OmnipathR] Loaded data from RDS `/Users/biocbuild/Library/Caches/OmnipathR/3492392585ba05414edfae46801492076437d7e7-1.rds`.
[2025-11-20 20:42:15] [INFO] [OmnipathR] Loaded from cache: `https://omnipathdb.org/annotations?resources=PROGENy&license=academic`
[2025-11-20 20:42:15] [SUCCESS] [OmnipathR] Loaded 699831 annotation records from cache.
[2025-11-20 20:42:18] [INFO] [OmnipathR] Loading database `Orthologous Matrix (OMA) gene pairs`.
[2025-11-20 20:42:18] [TRACE] [OmnipathR] Downloading by `generic_downloader`.
[2025-11-20 20:42:18] [TRACE] [OmnipathR] Looking up in cache: `https://omabrowser.org/All/oma-species.txt`.
[2025-11-20 20:42:18] [TRACE] [OmnipathR] Loaded data from RDS `/Users/biocbuild/Library/Caches/OmnipathR/30e690cbb55dfc63b5903ab337f34ffc2f4be397-1.rds`.
[2025-11-20 20:42:18] [TRACE] [OmnipathR] Downloading by `generic_downloader`.
[2025-11-20 20:42:18] [TRACE] [OmnipathR] Looking up in cache: `https://omabrowser.org/All/oma-species.txt`.
[2025-11-20 20:42:18] [TRACE] [OmnipathR] Loaded data from RDS `/Users/biocbuild/Library/Caches/OmnipathR/30e690cbb55dfc63b5903ab337f34ffc2f4be397-1.rds`.
[2025-11-20 20:42:18] [TRACE] [OmnipathR] Downloading by `generic_downloader`.
[2025-11-20 20:42:18] [TRACE] [OmnipathR] Looking up in cache: `https://omabrowser.org/api/pairs/HUMAN/MOUSE/?format=tsv&xrefs=UniProtKB%2FSwissProt&per_page=2000000`.
[2025-11-20 20:42:18] [INFO] [OmnipathR] Cache record does not exist: `https://omabrowser.org/api/pairs/HUMAN/MOUSE/?format=tsv&xrefs=UniProtKB%2FSwissProt&per_page=2000000`
[2025-11-20 20:42:18] [TRACE] [OmnipathR] Could not find in cache, initiating download: `https://omabrowser.org/api/pairs/HUMAN/MOUSE/?format=tsv&xrefs=UniProtKB%2FSwissProt&per_page=2000000`.
[2025-11-20 20:42:18] [TRACE] [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-11-20 20:42:18] [TRACE] [OmnipathR] JSON validation successful: TRUE
[2025-11-20 20:42:18] [TRACE] [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-11-20 20:42:18] [TRACE] [OmnipathR] JSON validation successful: TRUE
[2025-11-20 20:42:18] [INFO] [OmnipathR] Cache item `8f45b25c384d814c7de210e7ca40b7e35894e4f1` version 1: status changed from `unknown` to `started`.
[2025-11-20 20:42:18] [TRACE] [OmnipathR] Exporting object to RDS: `/Users/biocbuild/Library/Caches/OmnipathR/8f45b25c384d814c7de210e7ca40b7e35894e4f1-1.rds`.
[2025-11-20 20:42:18] [INFO] [OmnipathR] Retrieving URL: `https://omabrowser.org/api/pairs/HUMAN/MOUSE/?format=tsv&xrefs=UniProtKB%2FSwissProt&per_page=2000000`
[2025-11-20 20:42:18] [TRACE] [OmnipathR] Attempt 1/3: `https://omabrowser.org/api/pairs/HUMAN/MOUSE/?format=tsv&xrefs=UniProtKB%2FSwissProt&per_page=2000000`
[2025-11-20 20:42:19] [TRACE] [OmnipathR] HTTP request by `omnipath_curl`.
[2025-11-20 20:42:19] [TRACE] [OmnipathR] Curl options: [connecttimeout=10,timeout=300,debugfunction=<function>,verbose=FALSE,tcp_keepalive=TRUE,tcp_keepintvl=10,tcp_keepidle=10,tcp_keepcnt=13,upkeep_interval_ms=30000,ssl_verifypeer=1,ssl_verifyhost=2]
[2025-11-20 20:42:46] [TRACE] [OmnipathR] HTTP v2 GET: status 200.
[2025-11-20 20:42:46] [TRACE] [OmnipathR] Downloaded 11 Kb in 27.442059s from omabrowser.org (410 bytes/s); Redirect: 0s, DNS look up: 0.001201s, Connection: 0.002014s, Pretransfer: 0.401791s, First byte at: 27.441827s
[2025-11-20 20:42:46] [TRACE] [OmnipathR] HTTP headers: HTTP/2 200 ; date: Fri, 21 Nov 2025 01:42:46 GMT; server: nginx; strict-transport-security: max-age=31536000; includeSubDomains; content-type: text/tsv; charset=utf-8; content-length: 1187278; x-total-count: 22374; vary: Accept,origin,Cookie; allow: GET, HEAD, OPTIONS; content-disposition: attachment; filename=OMA-Pairs_HUMAN-MOUSE_2025-11-21_014244.tsv; x-frame-options: DENY; x-content-type-options: nosniff; referrer-policy: same-origin; cross-origin-opener-policy: same-origin; set-cookie: __matomo=1227dd34b549e26b; expires=Sun, 21-Nov-2027 01:42:46 UTC; Path=/
[2025-11-20 20:42:49] [TRACE] [OmnipathR] Exported RDS to `/Users/biocbuild/Library/Caches/OmnipathR/8f45b25c384d814c7de210e7ca40b7e35894e4f1-1.rds`.
[2025-11-20 20:42:49] [INFO] [OmnipathR] Download ready [key=8f45b25c384d814c7de210e7ca40b7e35894e4f1, version=1]
[2025-11-20 20:42:49] [TRACE] [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-11-20 20:42:49] [TRACE] [OmnipathR] JSON validation successful: TRUE
[2025-11-20 20:42:49] [INFO] [OmnipathR] Cache item `8f45b25c384d814c7de210e7ca40b7e35894e4f1` version 1: status changed from `started` to `ready`.
[2025-11-20 20:42:49] [TRACE] [OmnipathR] ID translation table: from `uniprot_entry` to `uniprot`, using `uniprot`.
[2025-11-20 20:42:49] [TRACE] [OmnipathR] Creating ID mapping table from `id` to `accession`, for organism 9606 (only reviewed: TRUE)
[2025-11-20 20:42:49] [TRACE] [OmnipathR] Loading all UniProt records for organism 9606 (only reviewed: TRUE); fields: id,accession
[2025-11-20 20:42:49] [TRACE] [OmnipathR] Downloading by `generic_downloader`.
[2025-11-20 20:42:49] [TRACE] [OmnipathR] Looking up in cache: `https://rest.uniprot.org/uniprotkb/stream?format=tsv&fields=id,accession&query=organism_id:9606%20AND%20reviewed:true`.
[2025-11-20 20:42:49] [INFO] [OmnipathR] Cache record does not exist: `https://rest.uniprot.org/uniprotkb/stream?format=tsv&fields=id,accession&query=organism_id:9606%20AND%20reviewed:true`
[2025-11-20 20:42:49] [TRACE] [OmnipathR] Could not find in cache, initiating download: `https://rest.uniprot.org/uniprotkb/stream?format=tsv&fields=id,accession&query=organism_id:9606%20AND%20reviewed:true`.
[2025-11-20 20:42:49] [TRACE] [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-11-20 20:42:49] [TRACE] [OmnipathR] JSON validation successful: TRUE
[2025-11-20 20:42:49] [TRACE] [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-11-20 20:42:49] [TRACE] [OmnipathR] JSON validation successful: TRUE
[2025-11-20 20:42:49] [INFO] [OmnipathR] Cache item `6558a1824894a625b8e3f80538cd3aa6e8a44379` version 1: status changed from `unknown` to `started`.
[2025-11-20 20:42:50] [TRACE] [OmnipathR] Exporting object to RDS: `/Users/biocbuild/Library/Caches/OmnipathR/6558a1824894a625b8e3f80538cd3aa6e8a44379-1.rds`.
[2025-11-20 20:42:50] [INFO] [OmnipathR] Retrieving URL: `https://rest.uniprot.org/uniprotkb/stream?format=tsv&fields=id,accession&query=organism_id:9606%20AND%20reviewed:true`
[2025-11-20 20:42:50] [TRACE] [OmnipathR] Attempt 1/3: `https://rest.uniprot.org/uniprotkb/stream?format=tsv&fields=id,accession&query=organism_id:9606%20AND%20reviewed:true`
[2025-11-20 20:42:50] [TRACE] [OmnipathR] HTTP request by `omnipath_curl`.
[2025-11-20 20:42:50] [TRACE] [OmnipathR] Curl options: [connecttimeout=10,timeout=300,debugfunction=<function>,verbose=FALSE,tcp_keepalive=TRUE,tcp_keepintvl=10,tcp_keepidle=10,tcp_keepcnt=13,upkeep_interval_ms=30000,ssl_verifypeer=1,ssl_verifyhost=2]
[2025-11-20 20:42:50] [TRACE] [OmnipathR] HTTP v2 GET: status 200.
[2025-11-20 20:42:50] [TRACE] [OmnipathR] Downloaded 31 bytes in 0.918229s from rest.uniprot.org (33 bytes/s); Redirect: 0s, DNS look up: 0.003389s, Connection: 0.004204s, Pretransfer: 0.560225s, First byte at: 0.918025s
[2025-11-20 20:42:50] [TRACE] [OmnipathR] HTTP headers: HTTP/2 200 ; vary: accept,accept-encoding,x-uniprot-release,x-api-deployment-date, User-Agent, Accept-Encoding; cache-control: public, max-age=43200; content-type: text/plain;format=tsv; content-encoding: gzip; access-control-allow-credentials: true; access-control-expose-headers: Link, X-Total-Results, X-UniProt-Release, X-UniProt-Release-Date, X-API-Deployment-Date; x-api-deployment-date: 03-November-2025; strict-transport-security: max-age=31536000; includeSubDomains; date: Fri, 21 Nov 2025 01:42:51 GMT; access-control-max-age: 1728000; x-uniprot-release: 2025_04; access-control-allow-origin: *; accept-ranges: bytes; access-control-allow-methods: GET, PUT, POST, DELETE, PATCH, OPTIONS; access-control-allow-headers: DNT,Keep-Alive,User-Agent,X-Requested-With,If-Modified-Since,Cache-Control,Content-Type,Range,Authorization; x-uniprot-release-date: 15-October-2025
[2025-11-20 20:43:02] [TRACE] [OmnipathR] Exported RDS to `/Users/biocbuild/Library/Caches/OmnipathR/6558a1824894a625b8e3f80538cd3aa6e8a44379-1.rds`.
[2025-11-20 20:43:02] [INFO] [OmnipathR] Download ready [key=6558a1824894a625b8e3f80538cd3aa6e8a44379, version=1]
[2025-11-20 20:43:02] [TRACE] [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-11-20 20:43:02] [TRACE] [OmnipathR] JSON validation successful: TRUE
[2025-11-20 20:43:02] [INFO] [OmnipathR] Cache item `6558a1824894a625b8e3f80538cd3aa6e8a44379` version 1: status changed from `started` to `ready`.
[2025-11-20 20:43:02] [SUCCESS] [OmnipathR] UniProt (rest.uniprot.org): downloaded 20420 records
[2025-11-20 20:43:03] [TRACE] [OmnipathR] Translating complexes: 0 complexes in data.
[2025-11-20 20:43:03] [TRACE] [OmnipathR] 0 complexes after removing the ones mapping to more than 1 items in target identifier space.
[2025-11-20 20:43:03] [TRACE] [OmnipathR] Translated 0 complexes to 0.
[2025-11-20 20:43:03] [TRACE] [OmnipathR] 13774 rows before translation, 13774 uniprot_entry IDs in column `id_organism_a`.
[2025-11-20 20:43:03] [TRACE] [OmnipathR] 13774 rows after translation; translated 13550 `uniprot_entry` IDs in column `id_organism_a` to 13550 `uniprot` IDs in column `id_organism_a`.
[2025-11-20 20:43:03] [TRACE] [OmnipathR] ID translation table: from `uniprot_entry` to `uniprot`, using `uniprot`.
[2025-11-20 20:43:03] [TRACE] [OmnipathR] Creating ID mapping table from `id` to `accession`, for organism 10090 (only reviewed: TRUE)
[2025-11-20 20:43:03] [TRACE] [OmnipathR] Loading all UniProt records for organism 10090 (only reviewed: TRUE); fields: id,accession
[2025-11-20 20:43:03] [TRACE] [OmnipathR] Downloading by `generic_downloader`.
[2025-11-20 20:43:03] [TRACE] [OmnipathR] Looking up in cache: `https://rest.uniprot.org/uniprotkb/stream?format=tsv&fields=id,accession&query=organism_id:10090%20AND%20reviewed:true`.
[2025-11-20 20:43:03] [INFO] [OmnipathR] Cache record does not exist: `https://rest.uniprot.org/uniprotkb/stream?format=tsv&fields=id,accession&query=organism_id:10090%20AND%20reviewed:true`
[2025-11-20 20:43:03] [TRACE] [OmnipathR] Could not find in cache, initiating download: `https://rest.uniprot.org/uniprotkb/stream?format=tsv&fields=id,accession&query=organism_id:10090%20AND%20reviewed:true`.
[2025-11-20 20:43:03] [TRACE] [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-11-20 20:43:03] [TRACE] [OmnipathR] JSON validation successful: TRUE
[2025-11-20 20:43:03] [TRACE] [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-11-20 20:43:03] [TRACE] [OmnipathR] JSON validation successful: TRUE
[2025-11-20 20:43:03] [INFO] [OmnipathR] Cache item `43ea5f2cdaa9ac7e0e114371af97235cdddd776f` version 1: status changed from `unknown` to `started`.
[2025-11-20 20:43:03] [TRACE] [OmnipathR] Exporting object to RDS: `/Users/biocbuild/Library/Caches/OmnipathR/43ea5f2cdaa9ac7e0e114371af97235cdddd776f-1.rds`.
[2025-11-20 20:43:03] [INFO] [OmnipathR] Retrieving URL: `https://rest.uniprot.org/uniprotkb/stream?format=tsv&fields=id,accession&query=organism_id:10090%20AND%20reviewed:true`
[2025-11-20 20:43:03] [TRACE] [OmnipathR] Attempt 1/3: `https://rest.uniprot.org/uniprotkb/stream?format=tsv&fields=id,accession&query=organism_id:10090%20AND%20reviewed:true`
[2025-11-20 20:43:03] [TRACE] [OmnipathR] HTTP request by `omnipath_curl`.
[2025-11-20 20:43:03] [TRACE] [OmnipathR] Curl options: [connecttimeout=10,timeout=300,debugfunction=<function>,verbose=FALSE,tcp_keepalive=TRUE,tcp_keepintvl=10,tcp_keepidle=10,tcp_keepcnt=13,upkeep_interval_ms=30000,ssl_verifypeer=1,ssl_verifyhost=2]
[2025-11-20 20:43:04] [TRACE] [OmnipathR] HTTP v2 GET: status 200.
[2025-11-20 20:43:04] [TRACE] [OmnipathR] Downloaded 31 bytes in 0.87077s from rest.uniprot.org (35 bytes/s); Redirect: 0s, DNS look up: 0.001133s, Connection: 0.002192s, Pretransfer: 0.542421s, First byte at: 0.870633s
[2025-11-20 20:43:04] [TRACE] [OmnipathR] HTTP headers: HTTP/2 200 ; vary: accept,accept-encoding,x-uniprot-release,x-api-deployment-date, User-Agent, Accept-Encoding; cache-control: public, max-age=43200; content-type: text/plain;format=tsv; content-encoding: gzip; access-control-allow-credentials: true; access-control-expose-headers: Link, X-Total-Results, X-UniProt-Release, X-UniProt-Release-Date, X-API-Deployment-Date; x-api-deployment-date: 03-November-2025; strict-transport-security: max-age=31536000; includeSubDomains; date: Fri, 21 Nov 2025 01:43:04 GMT; access-control-max-age: 1728000; x-uniprot-release: 2025_04; access-control-allow-origin: *; accept-ranges: bytes; access-control-allow-methods: GET, PUT, POST, DELETE, PATCH, OPTIONS; access-control-allow-headers: DNT,Keep-Alive,User-Agent,X-Requested-With,If-Modified-Since,Cache-Control,Content-Type,Range,Authorization; x-uniprot-release-date: 15-October-2025
[2025-11-20 20:43:11] [TRACE] [OmnipathR] Exported RDS to `/Users/biocbuild/Library/Caches/OmnipathR/43ea5f2cdaa9ac7e0e114371af97235cdddd776f-1.rds`.
[2025-11-20 20:43:11] [INFO] [OmnipathR] Download ready [key=43ea5f2cdaa9ac7e0e114371af97235cdddd776f, version=1]
[2025-11-20 20:43:11] [TRACE] [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-11-20 20:43:11] [TRACE] [OmnipathR] JSON validation successful: TRUE
[2025-11-20 20:43:12] [INFO] [OmnipathR] Cache item `43ea5f2cdaa9ac7e0e114371af97235cdddd776f` version 1: status changed from `started` to `ready`.
[2025-11-20 20:43:12] [SUCCESS] [OmnipathR] UniProt (rest.uniprot.org): downloaded 17240 records
[2025-11-20 20:43:12] [TRACE] [OmnipathR] Translating complexes: 0 complexes in data.
[2025-11-20 20:43:12] [TRACE] [OmnipathR] 0 complexes after removing the ones mapping to more than 1 items in target identifier space.
[2025-11-20 20:43:12] [TRACE] [OmnipathR] Translated 0 complexes to 0.
[2025-11-20 20:43:12] [TRACE] [OmnipathR] 13774 rows before translation, 13773 uniprot_entry IDs in column `id_organism_b`.
[2025-11-20 20:43:12] [TRACE] [OmnipathR] 13774 rows after translation; translated 13253 `uniprot_entry` IDs in column `id_organism_b` to 13253 `uniprot` IDs in column `id_organism_b`.
[2025-11-20 20:43:12] [INFO] [OmnipathR] Loaded database `Orthologous Matrix (OMA) gene pairs`.
[2025-11-20 20:43:12] [TRACE] [OmnipathR] ID translation table: from `uniprot` to `genesymbol`, using `uniprot`.
[2025-11-20 20:43:12] [TRACE] [OmnipathR] Creating ID mapping table from `accession` to `gene_primary`, for organism 10090 (only reviewed: TRUE)
[2025-11-20 20:43:12] [TRACE] [OmnipathR] Loading all UniProt records for organism 10090 (only reviewed: TRUE); fields: accession,gene_primary
[2025-11-20 20:43:12] [TRACE] [OmnipathR] Downloading by `generic_downloader`.
[2025-11-20 20:43:12] [TRACE] [OmnipathR] Looking up in cache: `https://rest.uniprot.org/uniprotkb/stream?format=tsv&fields=accession,gene_primary&query=organism_id:10090%20AND%20reviewed:true`.
[2025-11-20 20:43:12] [INFO] [OmnipathR] Cache record does not exist: `https://rest.uniprot.org/uniprotkb/stream?format=tsv&fields=accession,gene_primary&query=organism_id:10090%20AND%20reviewed:true`
[2025-11-20 20:43:12] [TRACE] [OmnipathR] Could not find in cache, initiating download: `https://rest.uniprot.org/uniprotkb/stream?format=tsv&fields=accession,gene_primary&query=organism_id:10090%20AND%20reviewed:true`.
[2025-11-20 20:43:12] [TRACE] [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-11-20 20:43:12] [TRACE] [OmnipathR] JSON validation successful: TRUE
[2025-11-20 20:43:12] [TRACE] [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-11-20 20:43:12] [TRACE] [OmnipathR] JSON validation successful: TRUE
[2025-11-20 20:43:12] [INFO] [OmnipathR] Cache item `3ec84ba713c02573704adb50f1a94dab684df34b` version 1: status changed from `unknown` to `started`.
[2025-11-20 20:43:12] [TRACE] [OmnipathR] Exporting object to RDS: `/Users/biocbuild/Library/Caches/OmnipathR/3ec84ba713c02573704adb50f1a94dab684df34b-1.rds`.
[2025-11-20 20:43:12] [INFO] [OmnipathR] Retrieving URL: `https://rest.uniprot.org/uniprotkb/stream?format=tsv&fields=accession,gene_primary&query=organism_id:10090%20AND%20reviewed:true`
[2025-11-20 20:43:12] [TRACE] [OmnipathR] Attempt 1/3: `https://rest.uniprot.org/uniprotkb/stream?format=tsv&fields=accession,gene_primary&query=organism_id:10090%20AND%20reviewed:true`
[2025-11-20 20:43:12] [TRACE] [OmnipathR] HTTP request by `omnipath_curl`.
[2025-11-20 20:43:12] [TRACE] [OmnipathR] Curl options: [connecttimeout=10,timeout=300,debugfunction=<function>,verbose=FALSE,tcp_keepalive=TRUE,tcp_keepintvl=10,tcp_keepidle=10,tcp_keepcnt=13,upkeep_interval_ms=30000,ssl_verifypeer=1,ssl_verifyhost=2]
[2025-11-20 20:43:13] [TRACE] [OmnipathR] HTTP v2 GET: status 200.
[2025-11-20 20:43:13] [TRACE] [OmnipathR] Downloaded 43 bytes in 0.596364s from rest.uniprot.org (72 bytes/s); Redirect: 0s, DNS look up: 0.001125s, Connection: 0.002178s, Pretransfer: 0.262682s, First byte at: 0.596182s
[2025-11-20 20:43:13] [TRACE] [OmnipathR] HTTP headers: HTTP/2 200 ; vary: accept,accept-encoding,x-uniprot-release,x-api-deployment-date, User-Agent, Accept-Encoding; cache-control: public, max-age=43200; content-type: text/plain;format=tsv; content-encoding: gzip; access-control-allow-credentials: true; access-control-expose-headers: Link, X-Total-Results, X-UniProt-Release, X-UniProt-Release-Date, X-API-Deployment-Date; x-api-deployment-date: 03-November-2025; strict-transport-security: max-age=31536000; includeSubDomains; date: Fri, 21 Nov 2025 01:43:13 GMT; access-control-max-age: 1728000; x-uniprot-release: 2025_04; access-control-allow-origin: *; accept-ranges: bytes; access-control-allow-methods: GET, PUT, POST, DELETE, PATCH, OPTIONS; access-control-allow-headers: DNT,Keep-Alive,User-Agent,X-Requested-With,If-Modified-Since,Cache-Control,Content-Type,Range,Authorization; x-uniprot-release-date: 15-October-2025
[2025-11-20 20:43:20] [TRACE] [OmnipathR] Exported RDS to `/Users/biocbuild/Library/Caches/OmnipathR/3ec84ba713c02573704adb50f1a94dab684df34b-1.rds`.
[2025-11-20 20:43:20] [INFO] [OmnipathR] Download ready [key=3ec84ba713c02573704adb50f1a94dab684df34b, version=1]
[2025-11-20 20:43:20] [TRACE] [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-11-20 20:43:20] [TRACE] [OmnipathR] JSON validation successful: TRUE
[2025-11-20 20:43:20] [INFO] [OmnipathR] Cache item `3ec84ba713c02573704adb50f1a94dab684df34b` version 1: status changed from `started` to `ready`.
[2025-11-20 20:43:20] [SUCCESS] [OmnipathR] UniProt (rest.uniprot.org): downloaded 17240 records
[2025-11-20 20:43:21] [TRACE] [OmnipathR] Translating complexes: 0 complexes in data.
[2025-11-20 20:43:21] [TRACE] [OmnipathR] 0 complexes after removing the ones mapping to more than 1 items in target identifier space.
[2025-11-20 20:43:21] [TRACE] [OmnipathR] Translated 0 complexes to 0.
[2025-11-20 20:43:21] [TRACE] [OmnipathR] 163908 rows before translation, 12855 uniprot IDs in column `uniprot`.
[2025-11-20 20:43:21] [TRACE] [OmnipathR] 163908 rows after translation; translated 12855 `uniprot` IDs in column `uniprot` to 12769 `genesymbol` IDs in column `genesymbol`.
[2025-11-20 20:43:21] [TRACE] [OmnipathR] Processing args for OmniPath query
[2025-11-20 20:43:21] [TRACE] [OmnipathR] Arguments for OmniPath query: [dorothea_levels=[A,B,C,D],genesymbols=TRUE,organisms=9606,query_type=interactions,datasets=dorothea]
[2025-11-20 20:43:21] [TRACE] [OmnipathR] Organism(s): 9606
[2025-11-20 20:43:21] [TRACE] [OmnipathR] Orthology targets:
[2025-11-20 20:43:21] [TRACE] [OmnipathR] Looking up in cache: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=dorothea&organisms=9606&dorothea_levels=A,B,C,D&fields=sources,references,curation_effort,dorothea_level&license=academic`
[2025-11-20 20:43:21] [INFO] [OmnipathR] Cache record does not exist: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=dorothea&organisms=9606&dorothea_levels=A,B,C,D&fields=sources,references,curation_effort,dorothea_level&license=academic`
[2025-11-20 20:43:21] [TRACE] [OmnipathR] Looking up in cache: `http://no-tls.omnipathdb.org/interactions?genesymbols=yes&datasets=dorothea&organisms=9606&dorothea_levels=A,B,C,D&fields=sources,references,curation_effort,dorothea_level&license=academic`
[2025-11-20 20:43:21] [INFO] [OmnipathR] Cache record does not exist: `http://no-tls.omnipathdb.org/interactions?genesymbols=yes&datasets=dorothea&organisms=9606&dorothea_levels=A,B,C,D&fields=sources,references,curation_effort,dorothea_level&license=academic`
[2025-11-20 20:43:21] [TRACE] [OmnipathR] Attempting `https://omnipathdb.org/interactions?genesymbols=yes&datasets=dorothea&organisms=9606&dorothea_levels=A,B,C,D&fields=sources,references,curation_effort,dorothea_level&license=academic`
[2025-11-20 20:43:21] [INFO] [OmnipathR] Retrieving URL: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=dorothea&organisms=9606&dorothea_levels=A,B,C,D&fields=sources,references,curation_effort,dorothea_level&license=academic`
[2025-11-20 20:43:21] [TRACE] [OmnipathR] Attempt 1/3: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=dorothea&organisms=9606&dorothea_levels=A,B,C,D&fields=sources,references,curation_effort,dorothea_level&license=academic`
[2025-11-20 20:43:21] [TRACE] [OmnipathR] HTTP request by `omnipath_curl`.
[2025-11-20 20:43:21] [TRACE] [OmnipathR] Curl options: [connecttimeout=10,timeout=300,debugfunction=<function>,verbose=FALSE,tcp_keepalive=TRUE,tcp_keepintvl=10,tcp_keepidle=10,tcp_keepcnt=13,upkeep_interval_ms=30000,ssl_verifypeer=1,ssl_verifyhost=2]
[2025-11-20 20:43:22] [TRACE] [OmnipathR] HTTP v1 GET: status 200.
[2025-11-20 20:43:22] [TRACE] [OmnipathR] Downloaded 15.7 Kb in 0.505918s from omnipathdb.org (31 Kb/s); Redirect: 0s, DNS look up: 0.001179s, Connection: 0.00227s, Pretransfer: 0.341826s, First byte at: 0.505578s
[2025-11-20 20:43:22] [TRACE] [OmnipathR] HTTP headers: HTTP/1.1 200 OK; Server: nginx; Date: Fri, 21 Nov 2025 01:43:22 GMT; Content-Type: text/plain; charset=utf-8; Transfer-Encoding: chunked; Connection: keep-alive; Cache-Control: max-age=3600; Access-Control-Allow-Origin: *; Expires: Fri, 21 Nov 2025 02:43:22 GMT; Cache-Control: public; X-Frame-Options: DENY; Content-Encoding: gzip
[2025-11-20 20:43:27] [INFO] [OmnipathR] Successfully retrieved: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=dorothea&organisms=9606&dorothea_levels=A,B,C,D&fields=sources,references,curation_effort,dorothea_level&license=academic`
[2025-11-20 20:43:27] [TRACE] [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-11-20 20:43:28] [TRACE] [OmnipathR] JSON validation successful: TRUE
[2025-11-20 20:43:28] [TRACE] [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-11-20 20:43:28] [TRACE] [OmnipathR] JSON validation successful: TRUE
[2025-11-20 20:43:28] [INFO] [OmnipathR] Cache item `46d37339bbc3f9a05bb89ccb79278cf1233f5cdf` version 1: status changed from `unknown` to `started`.
[2025-11-20 20:43:28] [TRACE] [OmnipathR] Exporting object to RDS: `/Users/biocbuild/Library/Caches/OmnipathR/46d37339bbc3f9a05bb89ccb79278cf1233f5cdf-1.rds`.
[2025-11-20 20:43:31] [TRACE] [OmnipathR] Exported RDS to `/Users/biocbuild/Library/Caches/OmnipathR/46d37339bbc3f9a05bb89ccb79278cf1233f5cdf-1.rds`.
[2025-11-20 20:43:31] [INFO] [OmnipathR] Download ready [key=46d37339bbc3f9a05bb89ccb79278cf1233f5cdf, version=1]
[2025-11-20 20:43:31] [TRACE] [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-11-20 20:43:31] [TRACE] [OmnipathR] JSON validation successful: TRUE
[2025-11-20 20:43:31] [INFO] [OmnipathR] Cache item `46d37339bbc3f9a05bb89ccb79278cf1233f5cdf` version 1: status changed from `started` to `ready`.
[2025-11-20 20:43:42] [SUCCESS] [OmnipathR] Downloaded 278677 interactions.
[2025-11-20 20:43:56] [TRACE] [OmnipathR] Processing args for OmniPath query
[2025-11-20 20:43:56] [TRACE] [OmnipathR] Arguments for OmniPath query: [dorothea_levels=[A,B,C,D],genesymbols=TRUE,organisms=10090,query_type=interactions,datasets=dorothea]
[2025-11-20 20:43:56] [TRACE] [OmnipathR] Organism(s): 10090
[2025-11-20 20:43:56] [TRACE] [OmnipathR] Orthology targets:
[2025-11-20 20:43:56] [TRACE] [OmnipathR] Looking up in cache: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=dorothea&organisms=10090&dorothea_levels=A,B,C,D&fields=sources,references,curation_effort,dorothea_level&license=academic`
[2025-11-20 20:43:56] [INFO] [OmnipathR] Cache record does not exist: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=dorothea&organisms=10090&dorothea_levels=A,B,C,D&fields=sources,references,curation_effort,dorothea_level&license=academic`
[2025-11-20 20:43:56] [TRACE] [OmnipathR] Looking up in cache: `http://no-tls.omnipathdb.org/interactions?genesymbols=yes&datasets=dorothea&organisms=10090&dorothea_levels=A,B,C,D&fields=sources,references,curation_effort,dorothea_level&license=academic`
[2025-11-20 20:43:56] [INFO] [OmnipathR] Cache record does not exist: `http://no-tls.omnipathdb.org/interactions?genesymbols=yes&datasets=dorothea&organisms=10090&dorothea_levels=A,B,C,D&fields=sources,references,curation_effort,dorothea_level&license=academic`
[2025-11-20 20:43:56] [TRACE] [OmnipathR] Attempting `https://omnipathdb.org/interactions?genesymbols=yes&datasets=dorothea&organisms=10090&dorothea_levels=A,B,C,D&fields=sources,references,curation_effort,dorothea_level&license=academic`
[2025-11-20 20:43:56] [INFO] [OmnipathR] Retrieving URL: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=dorothea&organisms=10090&dorothea_levels=A,B,C,D&fields=sources,references,curation_effort,dorothea_level&license=academic`
[2025-11-20 20:43:56] [TRACE] [OmnipathR] Attempt 1/3: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=dorothea&organisms=10090&dorothea_levels=A,B,C,D&fields=sources,references,curation_effort,dorothea_level&license=academic`
[2025-11-20 20:43:56] [TRACE] [OmnipathR] HTTP request by `omnipath_curl`.
[2025-11-20 20:43:56] [TRACE] [OmnipathR] Curl options: [connecttimeout=10,timeout=300,debugfunction=<function>,verbose=FALSE,tcp_keepalive=TRUE,tcp_keepintvl=10,tcp_keepidle=10,tcp_keepcnt=13,upkeep_interval_ms=30000,ssl_verifypeer=1,ssl_verifyhost=2]
[2025-11-20 20:43:57] [TRACE] [OmnipathR] HTTP v1 GET: status 200.
[2025-11-20 20:43:57] [TRACE] [OmnipathR] Downloaded 15.7 Kb in 0.544133s from omnipathdb.org (28.8 Kb/s); Redirect: 0s, DNS look up: 0.001182s, Connection: 0.002005s, Pretransfer: 0.355856s, First byte at: 0.543598s
[2025-11-20 20:43:57] [TRACE] [OmnipathR] HTTP headers: HTTP/1.1 200 OK; Server: nginx; Date: Fri, 21 Nov 2025 01:43:57 GMT; Content-Type: text/plain; charset=utf-8; Transfer-Encoding: chunked; Connection: keep-alive; Cache-Control: max-age=3600; Access-Control-Allow-Origin: *; Expires: Fri, 21 Nov 2025 02:43:57 GMT; Cache-Control: public; X-Frame-Options: DENY; Content-Encoding: gzip
[2025-11-20 20:44:04] [INFO] [OmnipathR] Successfully retrieved: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=dorothea&organisms=10090&dorothea_levels=A,B,C,D&fields=sources,references,curation_effort,dorothea_level&license=academic`
[2025-11-20 20:44:04] [TRACE] [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-11-20 20:44:04] [TRACE] [OmnipathR] JSON validation successful: TRUE
[2025-11-20 20:44:04] [TRACE] [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-11-20 20:44:04] [TRACE] [OmnipathR] JSON validation successful: TRUE
[2025-11-20 20:44:04] [INFO] [OmnipathR] Cache item `ff347dedf78ef5e38c9c6d8eed291fa901aa3791` version 1: status changed from `unknown` to `started`.
[2025-11-20 20:44:04] [TRACE] [OmnipathR] Exporting object to RDS: `/Users/biocbuild/Library/Caches/OmnipathR/ff347dedf78ef5e38c9c6d8eed291fa901aa3791-1.rds`.
[2025-11-20 20:44:07] [TRACE] [OmnipathR] Exported RDS to `/Users/biocbuild/Library/Caches/OmnipathR/ff347dedf78ef5e38c9c6d8eed291fa901aa3791-1.rds`.
[2025-11-20 20:44:07] [INFO] [OmnipathR] Download ready [key=ff347dedf78ef5e38c9c6d8eed291fa901aa3791, version=1]
[2025-11-20 20:44:07] [TRACE] [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-11-20 20:44:07] [TRACE] [OmnipathR] JSON validation successful: TRUE
[2025-11-20 20:44:07] [INFO] [OmnipathR] Cache item `ff347dedf78ef5e38c9c6d8eed291fa901aa3791` version 1: status changed from `started` to `ready`.
[2025-11-20 20:44:17] [SUCCESS] [OmnipathR] Downloaded 249440 interactions.
[2025-11-20 20:44:29] [TRACE] [OmnipathR] Processing args for OmniPath query
[2025-11-20 20:44:29] [TRACE] [OmnipathR] Arguments for OmniPath query: [loops=TRUE,organisms=9606,genesymbols=TRUE,query_type=interactions,datasets=collectri]
[2025-11-20 20:44:29] [TRACE] [OmnipathR] Organism(s): 9606
[2025-11-20 20:44:29] [TRACE] [OmnipathR] Orthology targets:
[2025-11-20 20:44:29] [TRACE] [OmnipathR] Looking up in cache: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=collectri&organisms=9606&fields=sources,references,curation_effort&loops=yes&license=academic`
[2025-11-20 20:44:29] [INFO] [OmnipathR] Cache record does not exist: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=collectri&organisms=9606&fields=sources,references,curation_effort&loops=yes&license=academic`
[2025-11-20 20:44:29] [TRACE] [OmnipathR] Looking up in cache: `http://no-tls.omnipathdb.org/interactions?genesymbols=yes&datasets=collectri&organisms=9606&fields=sources,references,curation_effort&loops=yes&license=academic`
[2025-11-20 20:44:29] [INFO] [OmnipathR] Cache record does not exist: `http://no-tls.omnipathdb.org/interactions?genesymbols=yes&datasets=collectri&organisms=9606&fields=sources,references,curation_effort&loops=yes&license=academic`
[2025-11-20 20:44:29] [TRACE] [OmnipathR] Attempting `https://omnipathdb.org/interactions?genesymbols=yes&datasets=collectri&organisms=9606&fields=sources,references,curation_effort&loops=yes&license=academic`
[2025-11-20 20:44:29] [INFO] [OmnipathR] Retrieving URL: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=collectri&organisms=9606&fields=sources,references,curation_effort&loops=yes&license=academic`
[2025-11-20 20:44:29] [TRACE] [OmnipathR] Attempt 1/3: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=collectri&organisms=9606&fields=sources,references,curation_effort&loops=yes&license=academic`
[2025-11-20 20:44:29] [TRACE] [OmnipathR] HTTP request by `omnipath_curl`.
[2025-11-20 20:44:29] [TRACE] [OmnipathR] Curl options: [connecttimeout=10,timeout=300,debugfunction=<function>,verbose=FALSE,tcp_keepalive=TRUE,tcp_keepintvl=10,tcp_keepidle=10,tcp_keepcnt=13,upkeep_interval_ms=30000,ssl_verifypeer=1,ssl_verifyhost=2]
[2025-11-20 20:44:30] [TRACE] [OmnipathR] HTTP v1 GET: status 200.
[2025-11-20 20:44:30] [TRACE] [OmnipathR] Downloaded 15.7 Kb in 0.498773s from omnipathdb.org (31.4 Kb/s); Redirect: 0s, DNS look up: 0.001473s, Connection: 0.002531s, Pretransfer: 0.334706s, First byte at: 0.498147s
[2025-11-20 20:44:30] [TRACE] [OmnipathR] HTTP headers: HTTP/1.1 200 OK; Server: nginx; Date: Fri, 21 Nov 2025 01:44:30 GMT; Content-Type: text/plain; charset=utf-8; Transfer-Encoding: chunked; Connection: keep-alive; Cache-Control: max-age=3600; Access-Control-Allow-Origin: *; Expires: Fri, 21 Nov 2025 02:44:30 GMT; Cache-Control: public; X-Frame-Options: DENY; Content-Encoding: gzip
[2025-11-20 20:44:33] [INFO] [OmnipathR] Successfully retrieved: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=collectri&organisms=9606&fields=sources,references,curation_effort&loops=yes&license=academic`
[2025-11-20 20:44:33] [TRACE] [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-11-20 20:44:33] [TRACE] [OmnipathR] JSON validation successful: TRUE
[2025-11-20 20:44:33] [TRACE] [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-11-20 20:44:33] [TRACE] [OmnipathR] JSON validation successful: TRUE
[2025-11-20 20:44:33] [INFO] [OmnipathR] Cache item `b10176737ba43d460b13709623189f3911123779` version 1: status changed from `unknown` to `started`.
[2025-11-20 20:44:33] [TRACE] [OmnipathR] Exporting object to RDS: `/Users/biocbuild/Library/Caches/OmnipathR/b10176737ba43d460b13709623189f3911123779-1.rds`.
[2025-11-20 20:44:34] [TRACE] [OmnipathR] Exported RDS to `/Users/biocbuild/Library/Caches/OmnipathR/b10176737ba43d460b13709623189f3911123779-1.rds`.
[2025-11-20 20:44:34] [INFO] [OmnipathR] Download ready [key=b10176737ba43d460b13709623189f3911123779, version=1]
[2025-11-20 20:44:34] [TRACE] [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-11-20 20:44:34] [TRACE] [OmnipathR] JSON validation successful: TRUE
[2025-11-20 20:44:34] [INFO] [OmnipathR] Cache item `b10176737ba43d460b13709623189f3911123779` version 1: status changed from `started` to `ready`.
[2025-11-20 20:44:36] [SUCCESS] [OmnipathR] Downloaded 64979 interactions.
[2025-11-20 20:44:36] [TRACE] [OmnipathR] Processing args for OmniPath query
[2025-11-20 20:44:36] [TRACE] [OmnipathR] Arguments for OmniPath query: [genesymbols=TRUE,resources=CollecTRI,strict_evidences=TRUE,query_type=interactions,datasets=tf_mirna]
[2025-11-20 20:44:37] [TRACE] [OmnipathR] Organism(s): 9606
[2025-11-20 20:44:37] [TRACE] [OmnipathR] Orthology targets:
[2025-11-20 20:44:37] [TRACE] [OmnipathR] Reading JSON from `https://omnipathdb.org/resources` (encoding: UTF-8).
[2025-11-20 20:44:37] [TRACE] [OmnipathR] JSON validation successful: TRUE
[2025-11-20 20:44:37] [TRACE] [OmnipathR] Looking up in cache: `https://omnipathdb.org/interactions?genesymbols=yes&resources=CollecTRI&datasets=tf_mirna&organisms=9606&fields=evidences,sources,references,curation_effort&license=academic`
[2025-11-20 20:44:37] [INFO] [OmnipathR] Cache record does not exist: `https://omnipathdb.org/interactions?genesymbols=yes&resources=CollecTRI&datasets=tf_mirna&organisms=9606&fields=evidences,sources,references,curation_effort&license=academic`
[2025-11-20 20:44:37] [TRACE] [OmnipathR] Looking up in cache: `http://no-tls.omnipathdb.org/interactions?genesymbols=yes&resources=CollecTRI&datasets=tf_mirna&organisms=9606&fields=evidences,sources,references,curation_effort&license=academic`
[2025-11-20 20:44:37] [INFO] [OmnipathR] Cache record does not exist: `http://no-tls.omnipathdb.org/interactions?genesymbols=yes&resources=CollecTRI&datasets=tf_mirna&organisms=9606&fields=evidences,sources,references,curation_effort&license=academic`
[2025-11-20 20:44:37] [TRACE] [OmnipathR] Attempting `https://omnipathdb.org/interactions?genesymbols=yes&resources=CollecTRI&datasets=tf_mirna&organisms=9606&fields=evidences,sources,references,curation_effort&license=academic`
[2025-11-20 20:44:37] [INFO] [OmnipathR] Retrieving URL: `https://omnipathdb.org/interactions?genesymbols=yes&resources=CollecTRI&datasets=tf_mirna&organisms=9606&fields=evidences,sources,references,curation_effort&license=academic`
[2025-11-20 20:44:37] [TRACE] [OmnipathR] Attempt 1/3: `https://omnipathdb.org/interactions?genesymbols=yes&resources=CollecTRI&datasets=tf_mirna&organisms=9606&fields=evidences,sources,references,curation_effort&license=academic`
[2025-11-20 20:44:37] [TRACE] [OmnipathR] HTTP request by `omnipath_curl`.
[2025-11-20 20:44:37] [TRACE] [OmnipathR] Curl options: [connecttimeout=10,timeout=300,debugfunction=<function>,verbose=FALSE,tcp_keepalive=TRUE,tcp_keepintvl=10,tcp_keepidle=10,tcp_keepcnt=13,upkeep_interval_ms=30000,ssl_verifypeer=1,ssl_verifyhost=2]
[2025-11-20 20:44:38] [TRACE] [OmnipathR] HTTP v1 GET: status 200.
[2025-11-20 20:44:38] [TRACE] [OmnipathR] Downloaded 9 Kb in 0.250863s from omnipathdb.org (36.1 Kb/s); Redirect: 0s, DNS look up: 0.001087s, Connection: 0.002143s, Pretransfer: 0.168258s, First byte at: 0.250547s
[2025-11-20 20:44:38] [TRACE] [OmnipathR] HTTP headers: HTTP/1.1 200 OK; Server: nginx; Date: Fri, 21 Nov 2025 01:44:38 GMT; Content-Type: text/plain; charset=utf-8; Transfer-Encoding: chunked; Connection: keep-alive; Cache-Control: max-age=3600; Access-Control-Allow-Origin: *; Expires: Fri, 21 Nov 2025 02:44:38 GMT; Cache-Control: public; X-Frame-Options: DENY; Content-Encoding: gzip
[2025-11-20 20:44:39] [INFO] [OmnipathR] Successfully retrieved: `https://omnipathdb.org/interactions?genesymbols=yes&resources=CollecTRI&datasets=tf_mirna&organisms=9606&fields=evidences,sources,references,curation_effort&license=academic`
[2025-11-20 20:44:39] [TRACE] [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-11-20 20:44:39] [TRACE] [OmnipathR] JSON validation successful: TRUE
[2025-11-20 20:44:39] [TRACE] [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-11-20 20:44:39] [TRACE] [OmnipathR] JSON validation successful: TRUE
[2025-11-20 20:44:39] [INFO] [OmnipathR] Cache item `f7d34500401ba98803b7d2b26c48f64cee1eea1b` version 1: status changed from `unknown` to `started`.
[2025-11-20 20:44:39] [TRACE] [OmnipathR] Exporting object to RDS: `/Users/biocbuild/Library/Caches/OmnipathR/f7d34500401ba98803b7d2b26c48f64cee1eea1b-1.rds`.
[2025-11-20 20:44:39] [TRACE] [OmnipathR] Exported RDS to `/Users/biocbuild/Library/Caches/OmnipathR/f7d34500401ba98803b7d2b26c48f64cee1eea1b-1.rds`.
[2025-11-20 20:44:39] [INFO] [OmnipathR] Download ready [key=f7d34500401ba98803b7d2b26c48f64cee1eea1b, version=1]
[2025-11-20 20:44:39] [TRACE] [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-11-20 20:44:39] [TRACE] [OmnipathR] JSON validation successful: TRUE
[2025-11-20 20:44:39] [INFO] [OmnipathR] Cache item `f7d34500401ba98803b7d2b26c48f64cee1eea1b` version 1: status changed from `started` to `ready`.
[2025-11-20 20:44:39] [TRACE] [OmnipathR] Converting JSON column `evidences` to list.
[2025-11-20 20:44:39] [TRACE] [OmnipathR] Restricting interaction records to datasets: tf_mirna; and resources: CollecTRI
[2025-11-20 20:44:39] [TRACE] [OmnipathR] Filtering evidence columns: positive, negative, directed, undirected; to datasets: tf_mirna; and resources: CollecTRI; excluding resources: none
[2025-11-20 20:44:40] [SUCCESS] [OmnipathR] Downloaded 207 interactions.
[2025-11-20 20:44:40] [TRACE] [OmnipathR] Processing args for OmniPath query
[2025-11-20 20:44:40] [TRACE] [OmnipathR] Arguments for OmniPath query: [loops=TRUE,organisms=9606,genesymbols=TRUE,query_type=interactions,datasets=collectri]
[2025-11-20 20:44:40] [TRACE] [OmnipathR] Organism(s): 9606
[2025-11-20 20:44:40] [TRACE] [OmnipathR] Orthology targets:
[2025-11-20 20:44:40] [TRACE] [OmnipathR] Looking up in cache: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=collectri&organisms=9606&fields=sources,references,curation_effort&loops=yes&license=academic`
[2025-11-20 20:44:40] [TRACE] [OmnipathR] Loaded data from RDS `/Users/biocbuild/Library/Caches/OmnipathR/b10176737ba43d460b13709623189f3911123779-1.rds`.
[2025-11-20 20:44:40] [INFO] [OmnipathR] Loaded from cache: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=collectri&organisms=9606&fields=sources,references,curation_effort&loops=yes&license=academic`
[2025-11-20 20:44:43] [SUCCESS] [OmnipathR] Loaded 64979 interactions from cache.
[2025-11-20 20:44:43] [TRACE] [OmnipathR] Processing args for OmniPath query
[2025-11-20 20:44:43] [TRACE] [OmnipathR] Arguments for OmniPath query: [genesymbols=TRUE,resources=CollecTRI,strict_evidences=TRUE,query_type=interactions,datasets=tf_mirna]
[2025-11-20 20:44:43] [TRACE] [OmnipathR] Organism(s): 9606
[2025-11-20 20:44:43] [TRACE] [OmnipathR] Orthology targets:
[2025-11-20 20:44:43] [TRACE] [OmnipathR] Reading JSON from `https://omnipathdb.org/resources` (encoding: UTF-8).
[2025-11-20 20:44:44] [TRACE] [OmnipathR] JSON validation successful: TRUE
[2025-11-20 20:44:44] [TRACE] [OmnipathR] Looking up in cache: `https://omnipathdb.org/interactions?genesymbols=yes&resources=CollecTRI&datasets=tf_mirna&organisms=9606&fields=evidences,sources,references,curation_effort&license=academic`
[2025-11-20 20:44:44] [TRACE] [OmnipathR] Loaded data from RDS `/Users/biocbuild/Library/Caches/OmnipathR/f7d34500401ba98803b7d2b26c48f64cee1eea1b-1.rds`.
[2025-11-20 20:44:44] [INFO] [OmnipathR] Loaded from cache: `https://omnipathdb.org/interactions?genesymbols=yes&resources=CollecTRI&datasets=tf_mirna&organisms=9606&fields=evidences,sources,references,curation_effort&license=academic`
[2025-11-20 20:44:44] [TRACE] [OmnipathR] Converting JSON column `evidences` to list.
[2025-11-20 20:44:44] [TRACE] [OmnipathR] Restricting interaction records to datasets: tf_mirna; and resources: CollecTRI
[2025-11-20 20:44:44] [TRACE] [OmnipathR] Filtering evidence columns: positive, negative, directed, undirected; to datasets: tf_mirna; and resources: CollecTRI; excluding resources: none
[2025-11-20 20:44:45] [SUCCESS] [OmnipathR] Loaded 207 interactions from cache.
|
| | 0%
|
|======================================================================| 100%
|
| | 0%
|
|======================================================================| 100%
|
| | 0%
|
|======================================================================| 100%
|
| | 0%
|
|======================================================================| 100%
|
| | 0%
|
|======================================================================| 100%
|
| | 0%
|
|======================================================================| 100%
|
| | 0%
|
|======================================================================| 100%
|
| | 0%
|
|======================================================================| 100%
|
| | 0%
|
|======================================================================| 100%
|
| | 0%
|
|======================================================================| 100%
|
| | 0%
|
|======================================================================| 100%
|
| | 0%
|
|======================================================================| 100%
|
| | 0%
|
|=================================== | 50%
|
|======================================================================| 100%
|
| | 0%
|
|=================================== | 50%
|
|======================================================================| 100%
|
| | 0%
|
|=================================== | 50%
|
|======================================================================| 100%
|
| | 0%
|
|=================================== | 50%
|
|======================================================================| 100%
|
| | 0%
|
|=================================== | 50%
|
|======================================================================| 100%
|
| | 0%
|
|=================================== | 50%
|
|======================================================================| 100%
|
| | 0%
|
|=================================== | 50%
|
|======================================================================| 100%
|
| | 0%
|
|=================================== | 50%
|
|======================================================================| 100%
|
| | 0%
|
|=================================== | 50%
|
|======================================================================| 100%
|
| | 0%
|
|=================================== | 50%
|
|======================================================================| 100%
|
| | 0%
|
|=================================== | 50%
|
|======================================================================| 100%
|
| | 0%
|
|=================================== | 50%
|
|======================================================================| 100%
Attaching package: 'dplyr'
The following objects are masked from 'package:stats':
filter, lag
The following objects are masked from 'package:base':
intersect, setdiff, setequal, union
[ FAIL 0 | WARN 18 | SKIP 0 | PASS 35 ]
[ FAIL 0 | WARN 18 | SKIP 0 | PASS 35 ]
>
> proc.time()
user system elapsed
210.375 25.770 330.777
decoupleR.Rcheck/decoupleR-Ex.timings
| name | user | system | elapsed | |
| check_corr | 0.083 | 0.013 | 0.097 | |
| convert_f_defaults | 0.032 | 0.004 | 0.037 | |
| decouple | 0.001 | 0.001 | 0.001 | |
| dot-fit_preprocessing | 0.026 | 0.004 | 0.030 | |
| extract_sets | 0.028 | 0.002 | 0.030 | |
| filt_minsize | 0.049 | 0.002 | 0.055 | |
| get_collectri | 33.879 | 4.320 | 54.891 | |
| get_dorothea | 26.222 | 1.971 | 31.198 | |
| get_profile_of | 0.001 | 0.001 | 0.000 | |
| get_progeny | 7.293 | 0.675 | 18.272 | |
| get_resource | 0.855 | 0.075 | 2.916 | |
| get_toy_data | 0.003 | 0.000 | 0.004 | |
| intersect_regulons | 0.034 | 0.008 | 0.043 | |
| pipe | 0 | 0 | 0 | |
| pivot_wider_profile | 0.000 | 0.001 | 0.000 | |
| randomize_matrix | 0 | 0 | 0 | |
| rename_net | 0.046 | 0.009 | 0.055 | |
| run_aucell | 11.839 | 4.492 | 16.445 | |
| run_consensus | 2.801 | 0.899 | 3.881 | |
| run_fgsea | 25.819 | 1.331 | 27.299 | |
| run_gsva | 2.690 | 1.172 | 3.874 | |
| run_mdt | 0.190 | 0.057 | 0.255 | |
| run_mlm | 0.12 | 0.02 | 0.14 | |
| run_ora | 0.677 | 0.105 | 0.785 | |
| run_udt | 0.367 | 0.059 | 0.428 | |
| run_ulm | 0.102 | 0.020 | 0.121 | |
| run_viper | 1.073 | 0.467 | 1.574 | |
| run_wmean | 1.005 | 0.125 | 1.138 | |
| run_wsum | 0.831 | 0.104 | 0.939 | |
| show_methods | 0.067 | 0.016 | 0.083 | |
| show_resources | 0.079 | 0.020 | 6.722 | |
| tidyeval | 0.000 | 0.000 | 0.001 | |