--- title: "Archipelago: Visualising Variant Set Association Results" output: rmarkdown::html_vignette vignette: > %\VignetteIndexEntry{Archipelago: Visualising Variant Set Association Results} %\VignetteEngine{knitr::rmarkdown} %\VignetteEncoding{UTF-8} --- ```{r setup, include = FALSE} knitr::opts_chunk$set( collapse = TRUE, comment = "#>", fig.width = 9, fig.height = 5, out.width = "100%" ) library(archipelago) ``` ## Overview The `archipelago` package provides a graphical method for joint visualisation of variant-level and variant-set association results. The Archipelago plot displays variant set p-values together with individual variant signals within a unified genomic coordinate system. ## Example data The package provides example datasets. ```{r} data("vsat_pval", package = "archipelago") data("variant_pval", package = "archipelago") head(vsat_pval) head(variant_pval) ``` ## Basic Archipelago plot A plot can be generated directly using default settings. Temporary output paths are used so that no files are written to the package. ```{r} p_basic <- archipelago_plot( df1 = vsat_pval, df2 = variant_pval, output_path = tempfile(), output_raw = tempfile() ) p_basic ``` This produces the standard Archipelago plot with automatic colouring and layout. ## Using colour themes Built-in colour themes allow rapid visual changes. ```{r} p_theme <- archipelago_plot( df1 = vsat_pval, df2 = variant_pval, color_theme = "alice", output_path = tempfile(), output_raw = tempfile() ) p_theme ``` Several predefined themes are available. ## Fully customised plot All visual elements can be customised. A typical advanced use case: ```{r} custom_colors <- c("#9abfd8", "#cac1f3", "#371c4b", "#2a5b7f") p_custom <- archipelago_plot( df1 = vsat_pval, df2 = variant_pval, add_title = TRUE, plot_title = "Custom Archipelago Plot", add_subtitle = TRUE, plot_subtitle = "Variant set and variant signals", show_legend = TRUE, legend_position = "bottom", chr_ticks = TRUE, point_size = 0.6, point_size_large = 1.2, custom_colors = custom_colors, color_labels = c( "Chromosome A", "Chromosome B", "Highlighted variants", "Variant set result" ), crit_val_VSAT = 0.05 / 300, crit_val_single_variant = 5e-8, annotate_thresholds = TRUE, fig_width = 10, fig_height = 5, output_path = tempfile(), output_raw = tempfile(), file_type = "pdf" ) p_custom ``` This example demonstrates full control over layout, colours, thresholds, labels, and output. ## Output files Plots are saved automatically using the specified output paths and formats. In this vignette, temporary paths are used so files are not persisted. ## Summary Archipelago provides a compact visual summary linking variant-level and variant-set association results, supporting interpretation of aggregation analyses in genetic studies.