Package: metaRMST
Title: Meta-Analysis of RMSTD
Version: 1.0.0
Author: Isabelle Weir [aut, cre], Lu Tian [aut], Ludovic Trinquart [aut]
Maintainer: Isabelle Weir <iweir@bu.edu>
URL: https://github.com/iweir/metaRMST
Description: R implementation of a multivariate meta-analysis of randomized controlled trials (RCT) with the difference in restricted mean survival times (RMSTD). Use this package with individual patient level data from an RCT for a time-to-event outcome to determine combined effect estimates according to 4 methods: 1)  a univariate meta-analysis using observed treatment effects, 2) a univariate meta-analysis using effects predicted by fitted Royston-Parmar flexible parametric models, 3) multivariate meta-analysis with analytically derived covariance, 4) multivariate meta-analysis with bootstrap derived covariance. This package computes all combined effects and provides an RMSTD curve with combined effect estimates and their confidence intervals.
Depends: R (>= 3.4.0), rstpm2
Imports: mvmeta, meta, survival, survRM2, graphics
License: GPL-2
Encoding: UTF-8
LazyData: true
RoxygenNote: 6.1.0
NeedsCompilation: no
Packaged: 2018-12-09 20:28:46 UTC; Isabelle
Repository: CRAN
Date/Publication: 2018-12-18 10:30:06 UTC
Built: R 4.1.3; ; 2023-04-17 20:33:33 UTC; windows
