### R code from vignette source 'MAXtest.Rnw' ################################################### ### code chunk number 1: coin-setup ################################################### library("coin") set.seed(290875) library("xtable") xtable.table <- function(x, ...) { tab2 <- function(x, pre = NULL, totals = TRUE) { if (totals) { x <- cbind(x, Total = rowSums(x)) x <- rbind(x, Total = colSums(x)) } if (!is.null(pre)) cat(pre, " & ") cat(" & ", paste(colnames(x), collapse = " & "), "\\\\ \\hline \n") tmp <- sapply(1:nrow(x), function(i) { if (!is.null(pre)) cat(" & ") cat(rownames(x)[i], " & ", paste(x[i,], collapse = " & "), " \\\\ \n") }) } if (length(dim(x)) == 2) { tab2(x, ...) } else { for (i in 1:dim(x)[3]) tab2(x[,,i], pre = dimnames(x)[[3]][i], ...) } } ### psoriasis data `psoriasis` <- structure(list(gender = structure(as.integer(c(2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 2, 2, 1, 2, 2, 2, 1, 1, 1, 2, 1, 2, 1, 1, 2, 1, 1, 2, 1, 2, 1, 2, 2, 2, 2, 2, 2, 1, 2, 2, 2, 2, 1, 2, 2, 1, 1, 1, 1, 2, 2, 1, 1, 1, 1, 1, 2, 1, 1, 1, 2, 2, 2, 1, 1, 1, 1, 1, 1, 1, 2, 2, 2, 2, 1, 1, 1, 2, 1, 1, 1, 1, 2, 1, 1, 2, 2, 1, 1, 1, 1, 2, 2, 1, 1, 1, 1, 1, 1, 2, 2, 2, 1, 1, 1, 1, 1, 1, 2, 1, 1, 2, 1, 1, 2, 1, 1, 2, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 2, 2, 2, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 2, 2, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 2, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 2, 1, 1, 1, 2, 2, 2, 1, 1, 1, 1, 2, 1, 1, 1, 1, 2, 2, 2, 1, 2, 1, 1, 1, 1, 1, 2, 2, 2, 2, 2, 1, 1, 2, 1, 1, 2, 1, 1, 1, 2, 2, 1, 1, 2, 2, 2, 1, 1, 1, 1, 2, 1, 1, 2, 1, 2, 1, 1, 2, 1, 2, 1, 1, 1, 1, 2, 1, 2, 1, 2)), .Label = c("Male", "Female"), class = "factor"), group = structure(as.integer(c(1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3)), .Label = c("Control", "Early Onset", "Late Onset"), class = "factor"), TNFA_238 = structure(as.integer(c(2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 2, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 2, 1, 2, 1, 2, 1, 1, 1, 2, 1, 2, 2, 1, 2, 1, 1, 1, 2, 1, 1, 1, 2, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 2, 2, 2, 1, 1, 1, 2, 2, 1, 1, 1, 1, 2, 2, 1, 1, 1, 1, 1, 2, 2, 1, 1, 2, 2, 1, 1, 2, 2, 2, 1, 1, 3, 1, 1, 1, 2, 2, 1, 1, 1, 1, 2, 1, 1, 1, 1, 1, 1, 1, 1, 2, 2, 1, 1, 1, 1, 1, 1, 1, 1, 2, 1, 2, 1, 1, 2, 2, 2, 1, 1, 1, 1, 2, 2, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 2, 1, 1, 1, 1, 2, 1, 2, 1, 1, 1, 1, 2, 1, 1, 1, 1, 1, 1, 1, 2, 1, 1, 1, 1, 2, 1, 1, 1, 1, 1, 1, 1, 1, 2, 1, 1, 2, 1, 1, 1, 1, 1, 1, 1, 1, 1, 2, 1, 2, 2, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 2, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 2, 1, 2, 1, 2, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 2, 1, 2, 1)), .Label = c("GG", "GA", "AA"), class = "factor"), IL1B_511 = structure(as.integer(c(2, 1, 2, 2, 1, 2, 2, 2, 1, 3, 2, 3, 2, 2, 1, 2, 3, 1, 2, 2, 2, 2, 3, 2, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 2, 1, 2, 1, 2, 2, 2, 1, 1, 1, 1, 2, 2, 1, 1, 2, 2, 1, 1, 2, 1, 3, 2, 2, 1, 2, 1, 1, 1, 1, 1, 2, 2, 1, 2, 1, 2, 1, 1, 1, 1, 3, 2, 1, 1, 2, 2, 2, 2, 2, 1, 2, 1, 1, 2, 3, 1, 1, 2, 2, 2, 1, 3, 3, 2, 2, 3, 1, 3, 1, 1, 1, 3, 2, 2, 1, 2, 2, 1, 2, 3, 2, 2, 1, 3, 2, 3, 1, 2, 2, 1, 1, 2, 1, 1, 2, 1, 3, 2, 3, 2, 1, 1, 1, 1, 2, 1, 1, 1, 1, 1, 3, 1, 2, 2, 1, 1, 2, 2, 2, 1, 1, 2, 1, 1, 2, 1, 2, 2, 1, 1, 1, 3, 2, 3, 1, 2, 1, 1, 2, 2, 1, 2, 2, 1, 3, 1, 1, 2, 2, 1, 2, 1, 1, 2, 1, 2, 2, 2, 2, 1, 1, 1, 2, 1, 1, 1, 1, 1, 1, 2, 2, 1, 1, 2, 2, 1, 1, 1, 1, 1, 1, 2, 2, 2, 1, 2, 2, 2, 2, 1, 1, 3, 2, 1, 1, 2, 2, 1, 3, 2, 2, 2, 1, 3, 2, 1, 2, 3, 2, 2, 2, 1, 2, 2, 2, 2, 1, 3, 1, 1, 1, 1, 1, 2, 2, 1, 2, 1, 3, 2, 2, 2, 1, 3, 1, 2, 1, 1, 1, 1, 2, 1, 1, 1, 1, 2, 1, 2, 1, 2, 2, 1, 1, 1, 2, 1, 1, 1, 3, 2, 2, 2, 2, 2, 3, 2, 2, 1, 2, 2, 2, 1, 1, 2, 2, 2, 2, 2, 2, 2, 2, 1, 1, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 1, 2, 2, 2, 1, 1, 2, 3, 3, 1, 2, 2, 2, 2, 2, 2, 2, 1, 1, 2, 3, 2, 3, 1, 2, 1, 1, 2, 1, 2, 1, 2, 1, 1, 2, 1, 1, 2, 2, 1, 2, 2, 1, 1, 2, 1, 1, 1, 2, 2, 2, 1, 2, 1, 2, 2, 1, 1, 1, 2, 1, 1, 1, 2, 2, 1, 1, 3, 2, 2, 1, 1, 3, 1, 1, 1, 1, 1, 1, 2, 2, 2, 1, 1, 1, 1, 1, 1, 2, 1, 1, 2, 3, 2, 2, 3, 2, 2, 1, 2, 1, 2, 2, 2, 1, 1, 1, 2, 3, 2, 1, 1, 1, 1, 2, 2, 2, 2, 1, 1, 2, 1, 2, 2, 1, 2, 1, 2, 1, 2, 2, 1, 2, 3, 3, 1, 2, 2, 1, 1, 2, 1, 3, 1, 1, 2, 1, 2, 2, 2, 1, 3, 1, 1, 1, 2, 1, 2, 2, 1, 1, 1, 1, 1, 2, 1, 2, 1, 2, 3, 1, 2, 1, 2, 1, 2, 1, 1, 2, 1, 2, 1, 1, 1, 2, 3, 1, 1, 2, 1, 1, 1, 1, 1, 1, 1, 2, 2, 2, 3, 1, 1, 1, 1, 1, 2, 1, 2, 1, 1, 3, 1, 1, 1, 3, 1, 1, 1, 1, 1, 3, 2, 2, 1, 2, 1, 1, 1, 2, 2, 1, 1, 2, 2, 1, 2, 2, 2, 1, 1, 1, 1, 1, 3, 1, 2, 2, 1)), .Label = c("CC", "CT", "TT"), class = "factor")), .Names = c("gender", "group", "TNFA_238", "IL1B_511"), row.names = c("1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104", "105", "106", "107", "108", "109", "110", "111", "112", "113", "114", "115", "116", "117", "118", "119", "120", "121", "122", "123", "124", "125", "126", "127", "128", "129", "130", "131", "132", "133", "134", "135", "136", "137", "138", "139", "140", "141", "142", "143", "144", "145", "146", "147", "148", "149", "150", "151", "152", "153", "154", "155", "156", "157", "158", "159", "160", "161", "162", "163", "164", "165", "166", "167", "168", "169", "170", "171", "172", "173", "174", "175", "176", "177", "178", "179", "180", "181", "182", "183", "184", "185", "186", "187", "188", "189", "190", "191", "192", "193", "194", "195", "196", "197", "198", "199", "200", "201", "202", "203", "204", "205", "206", "207", "208", "209", "210", "211", "212", "213", "214", "215", "216", "217", "218", "219", "220", "221", "222", "223", "224", "225", "226", "227", "228", "229", "230", "231", "232", "233", "234", "235", "236", "237", "238", "239", "240", "241", "242", "243", "244", "245", "246", "247", "248", "249", "250", "251", "252", "253", "254", "255", "256", "257", "258", "259", "260", "261", "262", "263", "264", "265", "266", "267", "268", "269", "270", "271", "272", "273", "274", "275", "276", "277", "278", "279", "280", "281", "282", "283", "284", "285", "286", "287", "288", "289", "290", "291", "292", "293", "294", "295", "296", "297", "298", "299", "300", "301", "302", "303", "304", "305", "306", "307", "308", "309", "310", "311", "312", "313", "314", "315", "316", "317", "318", "319", "320", "321", "322", "323", "324", "325", "326", "327", "328", "329", "330", "331", "332", "333", "334", "335", "336", "337", "338", "339", "340", "341", "342", "343", "344", "345", "346", "347", "348", "349", "350", "351", "352", "353", "354", "355", "356", "357", "358", "359", "360", "361", "362", "363", "364", "365", "366", "367", "368", "369", "370", "371", "372", "373", "374", "375", "376", "377", "378", "379", "380", "381", "382", "383", "384", "385", "386", "387", "388", "389", "390", "391", "392", "393", "394", "395", "396", "397", "398", "399", "400", "401", "402", "403", "404", "405", "406", "407", "408", "409", "410", "411", "412", "413", "414", "415", "416", "417", "418", "419", "420", "421", "422", "423", "424", "425", "426", "427", "428", "429", "430", "431", "432", "433", "434", "435", "436", "437", "438", "439", "440", "441", "442", "443", "444", "445", "446", "447", "448", "449", "450", "451", "452", "453", "454", "455", "456", "457", "458", "459", "460", "461", "462", "463", "464", "465", "466", "467", "468", "469", "470", "471", "472", "473", "474", "475", "476", "477", "478", "479", "480", "481", "482", "483", "484", "485", "486", "487", "488", "489", "490", "491", "492", "493", "494", "495", "496", "497", "498", "499", "500", "501", "502", "503", "504", "505", "506", "507", "508", "509", "510", "511", "512", "513", "514", "515", "516", "517", "518", "519", "520", "521", "522", "523", "524", "525", "526", "527", "528", "529", "530", "531", "532", "533", "534", "535", "536", "537", "538", "539", "540", "541", "542", "543", "544", "545", "546", "547", "548", "549", "550", "551", "552", "553", "554", "555", "556", "557", "558", "559", "560", "561", "562", "563", "564", "565", "566", "567", "568", "569", "570", "571", "572", "573", "574", "575", "576"), class = "data.frame") ### Bagos & Nikolopoulos (2007) example. `diabetes` <- structure(list(Study = structure(c(1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L, 4L), .Label = c("S1", "S2", "S3", "S4"), class = "factor"), Group = structure(c(2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L), .Label = c("Cases", "Control"), class = "factor"), Locus = structure(c(1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 3L, 3L, 3L, 3L, 3L, 3L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 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1L, 1L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 1L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 2L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L, 3L), .Label = c("AA", "AB", "BB" ), class = "factor")), .Names = c("Study", "Group", "Locus" ), row.names = c(NA, 888L), class = "data.frame") ################################################### ### code chunk number 2: melanoma-table ################################################### me <- as.table(matrix(c( 6, 8, 10, 32, 47, 20), byrow = TRUE, nrow = 2, dimnames = list(Group = c("In situ", "Control"), Genotype = c("AA", "AG", "GG")))) me <- t(me) ################################################### ### code chunk number 3: melanoma-tabular ################################################### xtable.table(me) ################################################### ### code chunk number 4: melanoma-coin ################################################### add <- c(0, 1, 2) dom <- c(0, 1, 1) rec <- c(0, 0, 1) g <- function(x) { x <- unlist(x) cbind(dominant = dom[x], additive = add[x], recessive = rec[x]) } it <- independence_test(me, xtrafo = g, alternative = "greater") CA <- statistic(it, type = "linear") CAstand <- statistic(it, type = "standardized") pasympt <- pvalue(it, method = "single-step") itp <- independence_test(me, xtrafo = g, distribution = approximate(nresample = 49999), alternative = "greater") papprox <- pvalue(itp, method = "step-down") out <- cbind(CA, round(expectation(it), 4), round(sqrt(variance(it)), 4), round(CAstand, 4), round(pasympt, 4), round(papprox, 4)) rownames(out) <- rownames(CA) out[,2] <- formatC(out[,2], digits = 4, format = "f") ################################################### ### code chunk number 5: melanoma-cov ################################################### S <- round(covariance(it), 4) S <- formatC(S, digits = 4, format = "f") for (i in 1:nrow(S)) cat(paste(S[i,], collapse = " & "), "\\\\ \n") ################################################### ### code chunk number 6: melanoma-cor ################################################### S <- round(cov2cor(covariance(it)), 4) S <- formatC(S, digits = 4, format = "f") for (i in 1:nrow(S)) cat(paste(S[i,], collapse = " & "), "\\\\ \n") ################################################### ### code chunk number 7: melanoma-results ################################################### for (i in 1:nrow(out)) cat(rownames(out)[i], " & ", paste(out[i,], collapse = " & "), "\\\\ \n") ################################################### ### code chunk number 8: Reich-data-1 ################################################### xtable(xtabs(~ IL1B_511 + group + gender, data = psoriasis)) ################################################### ### code chunk number 9: Reich-data-2 ################################################### xtable(xtabs(~ TNFA_238 + group + gender, data = psoriasis)) ################################################### ### code chunk number 10: ps ################################################### it <- independence_test(TNFA_238 + IL1B_511 ~ group | gender, data = psoriasis, ytrafo = function(data) trafo(data, factor_trafo = g), scores = list(group = c(1, -1/2, -1/2)), alter = "tw") pvals <- matrix(round(pvalue(it, method = "single-step"), 4), nr = 3) pvals[pvals < 0.01] <- "$< 0.0001$" rownames(pvals) <- c("dominant", "additive", "recessive") ################################################### ### code chunk number 11: ps-res ################################################### for (i in 1:nrow(pvals)) cat(rownames(pvals)[i], " & ", paste(pvals[i,], collapse = "&"), "\\\\ \n") ################################################### ### code chunk number 12: bagos-coin ################################################### bit <- independence_test(Group ~ Locus | Study, data = diabetes, xtrafo = g, alternative = "greater") bCA <- statistic(bit, type = "linear") bCAstand <- statistic(bit, type = "standardized") bpasympt <- pvalue(bit, method = "single-step") bitp <- independence_test(Group ~ Locus | Study, data = diabetes, xtrafo = g, distribution = approximate(nresample = 49999), alternative = "greater") bpapprox <- pvalue(bitp, method = "step-down") out <- cbind(bCA, round(expectation(bit), 4), round(sqrt(variance(bit)), 4), round(bCAstand, 4), round(bpasympt, 4), round(bpapprox, 4)) rownames(out) <- rownames(bCA) out[,2] <- formatC(out[,2], digits = 4, format = "f") ################################################### ### code chunk number 13: diabetes-results ################################################### for (i in 1:nrow(out)) cat(rownames(out)[i], " & ", paste(out[i,], collapse = " & "), "\\\\ \n") ################################################### ### code chunk number 14: Ame-tab ################################################### me <- as.table(matrix(c( 6, 8, 10, 32, 47, 20), byrow = TRUE, nrow = 2, dimnames = list(Group = c("In situ", "Control"), Genotype = c("AA", "AG", "GG")))) me <- t(me) me ################################################### ### code chunk number 15: Ag ################################################### add <- c(0, 1, 2) dom <- c(0, 1, 1) rec <- c(0, 0, 1) g <- function(x) { x <- unlist(x) cbind(dominant = dom[x], additive = add[x], recessive = rec[x]) } ################################################### ### code chunk number 16: AMAX ################################################### library("coin") it <- independence_test(me, xtrafo = g, alternative = "greater") it ################################################### ### code chunk number 17: Ap (eval = FALSE) ################################################### ## pvalue(it, method = "single-step") ################################################### ### code chunk number 18: Ap ################################################### drop(pvalue(it, method = "single-step")) ################################################### ### code chunk number 19: Zheng-g ################################################### gZheng <- function(x) { x <- unlist(x) eta <- seq(from = 0, to = 1, by = 0.01) tr <- sapply(eta, function(n) c(0, n, 1)[x]) colnames(tr) <- paste("eta", eta, sep = "_") tr } itZ <- independence_test(me, xtrafo = gZheng, alternative = "greater") itZ ################################################### ### code chunk number 20: pZheng (eval = FALSE) ################################################### ## pvalue(itZ, method = "single-step") ################################################### ### code chunk number 21: pZheng ################################################### drop(pvalue(itZ, method = "single-step")) ################################################### ### code chunk number 22: Simulations (eval = FALSE) ################################################### ## library("coin") ## ## assocAS <- function(x, scores = 1:ncol(x), ...) { ## ## if (!is.table(x)) ## stop(sQuote("x"), " is not a table.") ## if (length(scores) != ncol(x)) ## stop("Length of ", sQuote(scores), " does not match ", sQuote("ncol(x)")) ## xtab <- as.vector(t(x)) ## ## tmpdat <- data.frame(groups = factor(rep(paste("G", 1:nrow(x), sep = ""), rowSums(x))), ## scores1 = rep(rep(scores, nrow(x)), xtab), ## scores2 = rep(rep(c(scores[1], scores[2], scores[2]), nrow(x)), xtab), ## scores3 = rep(rep(c(scores[1], scores[1], scores[2]), nrow(x)), xtab)) ## ## independence_test(scores1 + scores2 + scores3 ~ groups, data = tmpdat, ...) ## } ## ## set.seed(17057711) ## ## SIMG=function (sims,R,S,p,f0,f1,f2) ## { ## #sims=10000 ## #R=200; S=200; ## #p=0.2; f0=0.1; f1=0.1; f2=0.3 ## phi=f2*(p**2)+(2*f1)*((1-p)*p)+f0*((1-p)**2) ## p0=(f0*(1-p)**2)/phi ## p1=(2*f1*(1-p)*p)/phi ## p2=(f2*p**2)/phi ## q0=((1-f0)*(1-p)**2)/(1-phi) ## q1=(2*(1-f1)*(1-p)*p)/(1-phi) ## q2=((1-f2)*p**2)/(1-phi) ## Probs=list(c(p2,p1,p0), c(q2,q1,q0)) # ansteigend ## ntotal=c(R,S) ## ## assocASsim <- function(n = sims, ngroup = ntotal, ## probs =Probs, ## scores = 1:3, ...) { ## ## g1 <- rmultinom(n, ngroup[1], probs[[1]]) ## g2 <- rmultinom(n, ngroup[2], probs[[2]]) ## ## padj <- matrix(0, nrow = n, ncol = length(scores)) ## praw <- matrix(0, nrow = n, ncol = length(scores)) ## ## for (i in 1:n) { ## ## x <- as.table(rbind(g1[,i], g2[,i])) ## it <- assocAS(x, scores = scores, ...) ## ## ### adjusted p-value ## padj[i,] <- pvalue(it, method = "single-step") ## ## ### raw p-value ## praw[i,] <- pnorm(statistic(it, type = "standardized")) ## } ## list(padj = padj, praw = praw) ## } ## ## tw <- assocASsim(alternative = "less") ## ## ### minimum p-value erg=table(apply(tw$padj, 1, which.min)) ## welchmin=apply(tw$padj, 1, which.min) ## nwelc=factor(welchmin, levels=c(1,2,3)) ## kleinst=apply(tw$padj, 1, min) ## gg=kleinst<0.05 ## fgg=factor(gg, levels=c(TRUE, FALSE)) ## oma=table(nwelc,fgg) ## ## est1=oma[1,1]/sims ## est2=oma[2,1]/sims ## est3=oma[3,1]/sims ## estMax=length(which(tw$padj[,1]<0.05 | tw$padj[,2]<0.05 |tw$padj[,3]<0.05))/sims ## estA=length(which(tw$praw[,1]<0.05))/sims ## estR=length(which(tw$praw[,2]<0.05))/sims ## estD=length(which(tw$praw[,3]<0.05))/sims ## ergeb=c("Max"=estMax,"MaxA"=est1,"MaxR"=est2,"MaxD"=est3,"Add"=estA, "Rec"=estR, "Dom"=estD, ## "p"=p,"f0"=f0,"f1"=f1,"f2"=f2,"cas"=R, "con"=S ) ## ergeb ## } ## ## SIMG(sims=10000,R=200,S=200,p=0.5,f0=0.1,f1=0.1,f2=0.1) ## SIMG(sims=10000,R=200,S=200,p=0.5,f0=0.1,f1=0.187,f2=0.187) ## SIMG(sims=10000,R=200,S=200,p=0.5,f0=0.1,f1=0.15, f2=0.2) ## SIMG(sims=10000,R=200,S=200,p=0.5,f0=0.1,f1=0.1, f2=0.175) ## ## ## ## ## ## SIMG(sims=1000,R=180,S=220,p=0.5,f0=0.1,f1=0.187,f2=0.187) ## SIMG(sims=1000,R=150,S=250,p=0.5,f0=0.1,f1=0.187,f2=0.187) ## SIMG(sims=1000,R=100,S=300,p=0.5,f0=0.1,f1=0.187,f2=0.187) ## SIMG(sims=1000,R=180,S=220,p=0.5,f0=0.1,f1=0.15, f2=0.2) ## SIMG(sims=1000,R=150,S=250,p=0.5,f0=0.1,f1=0.15, f2=0.2) ## SIMG(sims=1000,R=100,S=300,p=0.5,f0=0.1,f1=0.15, f2=0.2) ## SIMG(sims=1000,R=180,S=220,p=0.5,f0=0.1,f1=0.1, f2=0.175) ## SIMG(sims=1000,R=150,S=250,p=0.5,f0=0.1,f1=0.1, f2=0.175) ## SIMG(sims=1000,R=100,S=300,p=0.5,f0=0.1,f1=0.1, f2=0.175) ## ## ## SIMG(sims=1000,R=220,S=180,p=0.5,f0=0.1,f1=0.187,f2=0.187) ## SIMG(sims=1000,R=250,S=150,p=0.5,f0=0.1,f1=0.187,f2=0.187) ## SIMG(sims=1000,R=300,S=100,p=0.5,f0=0.1,f1=0.187,f2=0.187) ## SIMG(sims=1000,R=220,S=180,p=0.5,f0=0.1,f1=0.15, f2=0.2) ## SIMG(sims=1000,R=250,S=150,p=0.5,f0=0.1,f1=0.15, f2=0.2) ## SIMG(sims=1000,R=300,S=100,p=0.5,f0=0.1,f1=0.15, f2=0.2) ## SIMG(sims=1000,R=220,S=180,p=0.5,f0=0.1,f1=0.1, f2=0.175) ## SIMG(sims=1000,R=250,S=150,p=0.5,f0=0.1,f1=0.1, f2=0.175) ## SIMG(sims=1000,R=300,S=100,p=0.5,f0=0.1,f1=0.1, f2=0.175) ## ## ## ## SIMG(sims=10000,R=200,S=200,p=0.5,f0=0.1,f1=0.1, f2=0.1) ## SIMG(sims=10000,R=180,S=220,p=0.5,f0=0.1,f1=0.1, f2=0.1) ## SIMG(sims=10000,R=150,S=250,p=0.5,f0=0.1,f1=0.1, f2=0.1) ## SIMG(sims=10000,R=100,S=300,p=0.5,f0=0.1,f1=0.1, f2=0.1) ## SIMG(sims=10000,R=300,S=100,p=0.5,f0=0.1,f1=0.1, f2=0.1) ## ## SIMG(sims=10000,R=200,S=200,p=0.5,f0=0.1,f1=0.187, f2=0.187) ## SIMG(sims=10000,R=200,S=200,p=0.5,f0=0.1,f1=0.15, f2=0.2) ## SIMG(sims=10000,R=200,S=200,p=0.5,f0=0.1,f1=0.1, f2=0.175) ## ## SIMG(sims=10000,R=100,S=100,p=0.2,f0=0.16,f1=0.26, f2=0.36) ## SIMG(sims=10000,R=100,S=100,p=0.2,f0=0.2,f1=0.2, f2=0.7) ## SIMG(sims=10000,R=100,S=100,p=0.2,f0=0.2,f1=0.35, f2=0.35) ## ## SIMG(sims=10000,R=300,S=100,p=0.5,f0=0.1,f1=0.187, f2=0.187) ## SIMG(sims=10000,R=300,S=100,p=0.5,f0=0.1,f1=0.15, f2=0.2) ## SIMG(sims=10000,R=300,S=100,p=0.5,f0=0.1,f1=0.1, f2=0.175) ## SIMG(sims=10000,R=100,S=300,p=0.5,f0=0.1,f1=0.187, f2=0.187) ## SIMG(sims=10000,R=100,S=300,p=0.5,f0=0.1,f1=0.15, f2=0.2) ## SIMG(sims=10000,R=100,S=300,p=0.5,f0=0.1,f1=0.1, f2=0.175)