Optimal Two-Stage Designs for Ordered Categorical Outcomes


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Documentation for package ‘OptOTrials’ version 1.0.2

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OptOTrials-package Optimal Two-Stage Designs for Ordered Categorical Outcomes
Decision_rule_M.F Decision fule for the F design based on the Mann-Whitney-Wilcoxon test with specified values of alpha1 and beta1
Decision_rule_M.FS Decision rule for the FS design based on the Mann-Whitney-Wilcoxon test with the specified values of alpha1, alpha2, and beta1
Decision_rule_M_1stage One-stage clinical trial design based on the Mann-Whitney-Wilcoxon test
Decision_rule_S.F Decision rule for the F design based on the score test with the specified values of alpha1 and beta1
Decision_rule_S.FS Decision rule of the FS design based on the score test with the specified values of alpha1, alpha2, and beta1
Decision_rule_S_1stage One-stage clinical trial design based on the score test
Decision_rule_W.F Decision rule of the F design based on the Win Odds test with the specified values of alpha1 and beta1
Decision_rule_W.FS Decision rule of the FS design based on the Win Odds test with the specified values of alpha1, alpha2, and beta1
Decision_rule_W_1stage One-stage clinical trial design based on the Win Odds test
op.1stage Performance evaluation of a one-stage design
op.F Performance evaluation of the F design
op.FS Performance evaluation of the FS design
OptOTrials Optimal Two-Stage Designs for Ordered Categorical Outcomes
p2_fun p2
pq_fun Calculation of pq
Proportional_odds_assumption Checking proportional odds assumption
p_minus p_minus
p_plus p_plus
QR_fun Calculateion of Q or R
ruleF Decision fule of the F design
ruleFS Decision fule of the FS design
theta Calculation of theta
V_S.over.nk Calcualtion of V
W_W Calculation of W