Type: Package
Title: Cystic Fibrosis Survival Prediction Model Based on Stanojevic Model
Version: 0.3.0
Maintainer: Amin Adibi <adibi@alumni.ubc.ca>
Description: Allows clinicians to predict survival probabilities over the next two years for cystic fibrosis patients, based on the clinical prediction models published in Stanojevic et al. (2019) <doi:10.1183/13993003.00224-2019>.
License: GPL-3
Encoding: UTF-8
LazyData: true
RoxygenNote: 7.1.0
NeedsCompilation: no
Packaged: 2020-05-05 00:46:47 UTC; maadibi
Author: Sanja Stanojevic [aut, cph], Jenna Sykes [aut, cph], George A. Whitmore [aut, cph], Shawn D. Aaron [aut, cph], Aida Kazemi [aut], Amin Adibi [aut, cre]
Repository: CRAN
Date/Publication: 2020-05-07 10:00:06 UTC

Predicts 1- and 2- year Mortality Prediction Models in Cystic Fibrosis (CF)

Description

Predicts 1- and 2- year Mortality Prediction Models in Cystic Fibrosis (CF)

Usage

predictcfmortality(
  age,
  male,
  fvc,
  fev1,
  fev1LastYear,
  bcepacia,
  underweight,
  nHosp,
  pancreaticInsufficient,
  CFRelatedDiabetes,
  ageAtDiagnosis
)

Arguments

age

Patient age, in years

male

A binary variable with 0 for females and 1 for males

fvc

FVC percent predicted in the current year (0-150)

fev1

FEV1 percent predicted in the current year (0-150)

fev1LastYear

FEV1 percent predicted in the preceding year (0-150)

bcepacia

A binary with 0 for no B. cepacia complex and 1 for B. cepacia complex

underweight

A binary with 1 for underweight (BMI < 18.5 if age >= 19 or BMI percentile <= 12% if age < 19)

nHosp

An integer number of hospitalizations in preceding year

pancreaticInsufficient

A binary taking 1 for pancreatic insufficient status and 0 otherwise

CFRelatedDiabetes

A binary variable for CF related diabetes

ageAtDiagnosis

A number for age at CF diagnosis in years

Value

1- and 2-year predicted mortality risk

Source

https://erj.ersjournals.com/content/early/2019/05/08/13993003.00224-2019

Examples

predictcfmortality (age = 16, male = 0, fvc = 66.7, fev1 = 47.4, fev1LastYear = 80.5, 
                    bcepacia = 0, underweight = 0, nHosp = 0, pancreaticInsufficient = 1, 
                    CFRelatedDiabetes = 0, ageAtDiagnosis = 0.9)
predictcfmortality (age = 40.4, male = 1, fvc = 25.7, fev1 = 19.2, fev1LastYear = 20, 
                    bcepacia = 1, underweight = 1, nHosp = 6, pancreaticInsufficient = 0, 
                    CFRelatedDiabetes = 0, ageAtDiagnosis = 27.2)
predictcfmortality (age = 44, male = 1, fvc = 72.95, fev1 = 55.5, fev1LastYear = 52.5, 
                    bcepacia = 0, underweight = 1, nHosp = 0, pancreaticInsufficient = 0, 
                    CFRelatedDiabetes = 0, ageAtDiagnosis = 29)