Package: pleioh2g
Type: Package
Title: Estimation of Pleiotropic Heritability from Genome-Wide
        Association Studies (GWAS) Summary Statistics
Version: 0.1.2
Authors@R: 
    c(
      person(given = "Yujie", family = "Zhao",
             role = c("aut", "cre"),
             email = "yujiezhao@hsph.harvard.edu")
    )
Description: Provides tools to compute unbiased pleiotropic heritability estimates of complex diseases from genome-wide association studies (GWAS) summary statistics. We estimate pleiotropic heritability from GWAS summary statistics by estimating the proportion of variance explained from an estimated genetic correlation matrix (Bulik-Sullivan et al. 2015 <doi:10.1038/ng.3406>) and employing a Monte-Carlo bias correction procedure to account for sampling noise in genetic correlation estimates. 
License: GPL-3
Encoding: UTF-8
LazyData: true
Depends: R (>= 2.10)
RoxygenNote: 7.3.2
Imports: data.table, dplyr, stats, rlang, mvtnorm, fs, arrow,
        checkmate, cli, gdata, glue, purrr, tibble, vroom
Suggests: knitr, rmarkdown, testthat (>= 3.0.0)
Config/testthat/edition: 3
VignetteBuilder: knitr
Language: en-US
NeedsCompilation: no
Packaged: 2026-03-09 13:26:35 UTC; yujiezhao
Author: Yujie Zhao [aut, cre]
Maintainer: Yujie Zhao <yujiezhao@hsph.harvard.edu>
Repository: CRAN
Date/Publication: 2026-03-09 14:00:02 UTC
Built: R 4.7.0; ; 2026-05-10 03:18:06 UTC; windows
