
<!-- Only modify this file in folder "vignettes"! -->

---
output: rmarkdown::html_vignette
vignette: >
  %\VignetteIndexEntry{article frame}
  %\VignetteEngine{knitr::rmarkdown}
  %\VignetteEncoding{UTF-8}
---

Click [here](https://www.biomedcentral.com/content/pdf/s12859-016-0961-5.pdf) to download article.

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