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### Running command:
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###   /Library/Frameworks/R.framework/Resources/bin/R CMD build --keep-empty-dirs --no-resave-data MutationalPatterns
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* checking for file ‘MutationalPatterns/DESCRIPTION’ ... OK
* preparing ‘MutationalPatterns’:
* checking DESCRIPTION meta-information ... OK
* installing the package to build vignettes
* creating vignettes ... ERROR
--- re-building ‘Introduction_to_MutationalPatterns.Rmd’ using rmarkdown

Quitting from Introduction_to_MutationalPatterns.Rmd:112-115 [unnamed-chunk-2]
~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
<error/rlang_error>
Error in `h()`:
! error in evaluating the argument 'x' in selecting a method for function 'head': Bioconductor version cannot be validated; no internet connection?  See #troubleshooting section
  in vignette
---
Backtrace:
     ▆
  1. ├─utils::head(available.genomes())
  2. ├─BSgenome::available.genomes()
  3. │ └─BSgenome:::get_data_annotation_contrib_url(type)
  4. │   ├─utils::contrib.url(BiocManager::repositories()["BioCann"], type = type)
  5. │   └─BiocManager::repositories()
  6. │     └─BiocManager:::.version_validate(version)
  7. │       ├─base::ifelse(.is_CRAN_check(), .message(txt), .stop(txt))
  8. │       └─BiocManager:::.stop(txt)
  9. │         └─base::stop(.msg(...), call. = call.)
 10. └─base::.handleSimpleError(...)
 11.   └─base (local) h(simpleError(msg, call))
~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~

Error: processing vignette 'Introduction_to_MutationalPatterns.Rmd' failed with diagnostics:
error in evaluating the argument 'x' in selecting a method for function 'head': Bioconductor version cannot be validated; no internet connection?  See #troubleshooting section
  in vignette
--- failed re-building ‘Introduction_to_MutationalPatterns.Rmd’

SUMMARY: processing the following file failed:
  ‘Introduction_to_MutationalPatterns.Rmd’

Error: Vignette re-building failed.
Execution halted