Package: iNETgrate
Type: Package
Title: Integrates DNA methylation data with gene expression in a single
        gene network
Version: 1.9.0
Date: 2023-03-24
Authors@R: c(
    person("Ghazal", "Ebrahimi", role = "aut"),
    person("Isha", "Mehta", role = "aut",
    comment = c(ORCID = "0000-0002-6009-0787")),
    person("Hanie", "Samimi", role = "aut"),
    person("Habil", "Zare", email = "zare@u.washington.edu",
    role = c("aut", "cre"), comment = c(ORCID = "0000-0001-5902-6238")))
biocViews: GeneExpression, RNASeq, DNAMethylation, NetworkInference,
        Network, GraphAndNetwork, BiomedicalInformatics,
        SystemsBiology, Transcriptomics, Classification, Clustering,
        DimensionReduction, PrincipalComponent, mRNAMicroarray,
        Normalization, GenePrediction, KEGG, Survival
Depends: R (>= 4.3.0), BiocStyle (>= 2.18.1)
Description: The iNETgrate package provides functions to build a
        correlation network in which nodes are genes. DNA methylation
        and gene expression data are integrated to define the
        connections between genes. This network is used to identify
        modules (clusters) of genes. The biological information in each
        of the resulting modules is represented by an eigengene. These
        biological signatures can be used as features e.g., for
        classification of patients into risk categories. The resulting
        biological signatures are very robust and give a holistic view
        of the underlying molecular changes.
Imports: SummarizedExperiment, GenomicRanges (>= 1.24.1), stats, WGCNA,
        grDevices, graphics, survival, igraph, Pigengene (>= 1.19.26),
        Homo.sapiens, glmnet, caret, gplots, minfi, matrixStats, Rfast,
        tidyr, tidyselect, utils
Suggests: knitr, org.Hs.eg.db, org.Mm.eg.db,
        IlluminaHumanMethylation450kanno.ilmn12.hg19, AnnotationDbi,
        sesameData, TCGAbiolinks (>= 2.29.4)
License: GPL-3
BugReports: https://github.com/Bioconductor/BiocManager/issues
VignetteBuilder: knitr
NeedsCompilation: no
Packaged: 2026-03-07 03:49:23 UTC; root
Author: Isha Mehta [aut] (<https://orcid.org/0000-0002-6009-0787>),
        Ghazal Ebrahimi [aut], Hanie Samimi [aut], Habil Zare [aut,
        cre] (<https://orcid.org/0000-0001-5902-6238>)
Maintainer: Habil Zare <zare@u.washington.edu>
Config/pak/sysreqs: libcairo2-dev libfontconfig1-dev libfreetype6-dev
        libglpk-dev make libbz2-dev libicu-dev liblzma-dev libpng-dev
        libxml2-dev libssl-dev libx11-dev xz-utils zlib1g-dev
Repository: https://bioc.r-universe.dev
Date/Publication: 2025-10-29 15:23:49 UTC
RemoteUrl: https://github.com/bioc/iNETgrate
RemoteRef: HEAD
RemoteSha: 81fc611ac9d611de1d9f7872f302f26cb819faf8
Built: R 4.6.0; ; 2026-03-07 03:55:38 UTC; windows
