Package: POWSC
Type: Package
Title: Simulation, power evaluation, and sample size recommendation for
        single cell RNA-seq
Version: 1.19.0
Authors@R: c(person("Kenong","Su", email ="kenong.su@emory.edu", role = c("aut","cre")),person("Hao","Wu", email ="hao.wu@emory.edu", role ="aut"))
Description: Determining the sample size for adequate power to detect
        statistical significance is a crucial step at the design stage
        for high-throughput experiments. Even though a number of
        methods and tools are available for sample size calculation for
        microarray and RNA-seq in the context of differential
        expression (DE), this topic in the field of single-cell RNA
        sequencing is understudied. Moreover, the unique data
        characteristics present in scRNA-seq such as sparsity and
        heterogeneity increase the challenge. We propose POWSC, a
        simulation-based method, to provide power evaluation and sample
        size recommendation for single-cell RNA sequencing DE analysis.
        POWSC consists of a data simulator that creates realistic
        expression data, and a power assessor that provides a
        comprehensive evaluation and visualization of the power and
        sample size relationship.
License: GPL-2
Encoding: UTF-8
LazyData: true
biocViews: DifferentialExpression, ImmunoOncology, SingleCell, Software
Depends: R (>= 4.1), Biobase, SingleCellExperiment, MAST
Imports: pheatmap, ggplot2, RColorBrewer, grDevices,
        SummarizedExperiment, limma
Suggests: rmarkdown, knitr, testthat (>= 3.0.0), BiocStyle
VignetteBuilder: knitr
RoxygenNote: 7.1.1
Config/pak/sysreqs: libicu-dev zlib1g-dev
Repository: https://bioc.r-universe.dev
Date/Publication: 2025-10-29 15:09:11 UTC
RemoteUrl: https://github.com/bioc/POWSC
RemoteRef: HEAD
RemoteSha: b092ca1591166c88271ef4e58cba831a774c6c99
NeedsCompilation: no
Packaged: 2026-03-19 08:07:04 UTC; root
Author: Kenong Su [aut, cre],
  Hao Wu [aut]
Maintainer: Kenong Su <kenong.su@emory.edu>
Built: R 4.6.0; ; 2026-03-19 08:08:53 UTC; windows
