LDAcoop: Analysis of Data from Limiting Dilution Assay (LDA) with or
without Cellular Cooperation
Cellular cooperation compromises the established method of
calculating clonogenic activity from limiting dilution assay (LDA) data.
This tool provides functions that enable robust analysis in presence or
absence of cellular cooperation. The implemented method incorporates the
same cooperativity module to model the non-linearity associated with
cellular cooperation as known from the colony formation assay (Brix et al.
(2021) <doi:10.1038/s41596-021-00615-0>: "Analysis of clonogenic growth in
vitro." Nature protocols).
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