HybridDesign: Hybrid Design for Phase I Dose-Finding Studies
The Hybrid design is a combination of model-assisted design (e.g., the modified
Toxicity Probability Interval design) with dose-toxicity model-based design for
phase I dose-finding studies. The hybrid design controls the overdosing
toxicity well and leads to a recommended dose closer to the true maximum tolerated
dose (MTD) due to its ability to calibrate for an intermediate dose. More details
can be found in Liao et al. 2022 <doi:10.1002/ijc.34203>.
Version: |
1.0 |
Depends: |
R (≥ 3.6) |
Imports: |
testit, ResourceSelection |
Published: |
2022-12-15 |
Author: |
Heng Zhou [aut, cre],
Feng Zhou [aut],
Jason Liao [aut] |
Maintainer: |
Heng Zhou <heng.zhou at merck.com> |
License: |
GPL-3 |
NeedsCompilation: |
no |
CRAN checks: |
HybridDesign results |
Documentation:
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