\name{findSigLevelFdr} \alias{findSigLevelFdr} %- Also NEED an '\alias' for EACH other topic documented here. \title{ This function has not been properly implemented yet } \description{ Method to find the cutoff at which gains and losses are considered significant using permutations } \usage{ findSigLevelFdr(data, observedSpm, n = 1, fdrTarget=0.05, maxmem=1000) } %- maybe also 'usage' for other objects documented here. \arguments{ \item{data}{ aCGH data in the same format as used for 'calcSpm' } \item{observedSpm}{ A sample point matrix as produced by 'calcSpm'} \item{n}{ Number of permutations } \item{fdrTarget}{ Target False Discovery Rate (FDR) } \item{maxmem}{ This parameter controls memory usage, set to lower value to lower memory consumption } } \details{ The number of permutations needed for reliable results depends on the data and can not be determined beforehand. As a general rule-of-thumb around 100 permutations should be used for 'quick checks' and around 2000 permutations for more rigorous testing. The FDR method is less conservatie than the p-value based approach since instead of controlling the family wise error rate (FWER, P(false positive > 1)) it controls the false discovery rate (FDR) (false positives / total number of called data points). } \value{ A list with the cutoffs corresponding to the given FDR \item{pos }{The cutoff for the gains} \item{neg }{The cutoff for the losses'} } \author{ Jorma de Ronde } \seealso{\code{\link{plotScaleSpace}} } \examples{ data(hsSampleData) data(hsMirrorLocs) spm1mb <- calcSpm(hsSampleData, hsMirrorLocs) sigLevel1mb <- findSigLevelTrad(hsSampleData, spm1mb, n=3) plot(spm1mb, sigLevels=sigLevel1mb) plotScaleSpace(list(spm1mb), list(sigLevel1mb), type='g') } % Add one or more standard keywords, see file 'KEYWORDS' in the % R documentation directory. \keyword{manip}